KEGG   DRUG: D02893Help
Entry
D02893                      Drug                                   

Name
Amesergide (USAN/INN)
Formula
C25H35N3O
Exact mass
393.278
Mol weight
393.5649
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Serotonin antagonist
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
5-HT2C-receptor antagonist [HSA:3358] [KO:K04157]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT2A-receptor
     Amesergide
      D02893  Amesergide (USAN/INN)
    5-HT2C-receptor
     Amesergide
      D02893  Amesergide (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
121588-75-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C8x C     3.8500  -16.1000
            2   C8x C     3.8500  -17.5000
            3   C8y C     5.0624  -18.2000
            4   C8y C     6.2749  -17.5000
            5   C8y C     6.2749  -16.1000
            6   C8x C     5.0624  -15.4000
            7   C8y C     7.4873  -18.2000
            8   C1x C     8.6997  -17.5000
            9   C1y C     8.6997  -16.1000
            10  C1y C     7.4873  -15.4000
            11  N1y N     9.9122  -15.4000
            12  C1x C     9.9122  -14.0000
            13  C1y C     8.6997  -13.3000
            14  C1x C     7.4873  -14.0000
            15  N4y N     5.0624  -19.5998
            16  C8x C     7.4873  -19.6000
            17  C1c C     4.0613  -20.6011
            18  C1a C     2.7026  -20.2372
            19  C1a C     4.4185  -21.9333
            20  C1a C    11.1453  -16.1122
            21  C5a C     8.6997  -11.9001
            22  O5a O     7.4725  -11.1915
            23  N1b N     9.8973  -11.2086
            24  C1y C    11.0855  -11.8946
            25  C1x C    11.0856  -13.2998
            26  C1x C    12.2981  -13.9997
            27  C1x C    13.5105  -13.2997
            28  C1x C    13.5104  -11.8945
            29  C1x C    12.2979  -11.1946
BOND        33
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17    3  15 1
            18    7  16 2
            19   15  16 1
            20   15  17 1
            21   17  18 1
            22   17  19 1
            23   11  20 1
            24   13  21 1 #Up
            25   21  22 2
            26   21  23 1
            27   23  24 1
            28   24  25 1
            29   25  26 1
            30   26  27 1
            31   27  28 1
            32   28  29 1
            33   24  29 1

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