| Entry |
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| Name |
Amlodipine maleate (USAN);
Amvaz (TN)
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| Formula |
C20H25ClN2O5. C4H4O4
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| Exact mass |
524.1562
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| Mol weight |
524.9481
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| Structure |
     |
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| Activity |
Anti-anginal;
Antihypertensive
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| Remark |
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| Comment |
Dihydropiridine calcium channel blocker
Indication: Hypertension
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577], CYP3A7 [HSA: 1551]
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| Interaction |
CYP inhibition: CYP3A [KO: K07424]
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| Structure map |
| Calcium channel blocking drugs |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA01 Amlodipine
D02914 Amlodipine maleate (USAN)
USP drug classification [BR:br08302]
Cardiovascular Agents
Calcium Channel Blocking Agents
Dihydropyridines
Amlodipine
D02914 Amlodipine maleate (USAN)
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated cation channels
Ca2+ channel, CACN alpha-1, CaVx.x
calcium channel L type [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
Amlodipine [ATC:C08CA01]
D02914 Amlodipine maleate (USAN)
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| Other DBs |
CAS: 88150-47-4 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 36
1 C6a C 28.6629 -16.1156
2 O6a O 29.3546 -17.3137
3 O6a O 31.2223 -17.3137
4 C6a C 31.9140 -16.1156
5 C2b C 31.2223 -14.9175
6 C2b C 29.3546 -14.9175
7 O6a O 33.2975 -16.1156
8 O6a O 27.2794 -16.1156
9 C1y C 21.0168 -13.2762
10 C2y C 22.1998 -12.5803
11 C2y C 19.8339 -12.5803
12 C8y C 21.0168 -15.6421
13 C2y C 22.1998 -11.1886
14 C7a C 23.3828 -13.2762
15 C2y C 19.8339 -11.1886
16 C7a C 18.6509 -13.2066
17 C8y C 22.1998 -16.3380
18 C8x C 19.8339 -16.3380
19 N1x N 21.0168 -10.4927
20 C1b C 23.3828 -10.4927
21 O7a O 24.5658 -12.5803
22 O6a O 23.3828 -14.5983
23 C1a C 18.6509 -10.4927
24 O7a O 17.4679 -12.5803
25 O6a O 18.6509 -14.5983
26 C8x C 22.1998 -17.6601
27 X Cl 23.3828 -15.6421
28 C8x C 19.8339 -17.6601
29 O2a O 24.5658 -11.1886
30 C1b C 25.7487 -13.2762
31 C1a C 16.2849 -13.2066
32 C8x C 21.0168 -18.3560
33 C1b C 25.7487 -10.4927
34 C1a C 26.9317 -12.5803
35 C1b C 26.9317 -11.1886
36 N1a N 28.1147 -10.4927
BOND 36
1 1 2 2
2 3 4 1
3 4 5 1
4 5 6 2
5 1 6 1
6 4 7 2
7 1 8 1
8 9 10 1
9 9 11 1
10 9 12 1
11 10 13 2
12 10 14 1
13 11 15 2
14 11 16 1
15 12 17 1
16 12 18 2
17 13 19 1
18 13 20 1
19 14 21 1
20 14 22 2
21 15 23 1
22 16 24 1
23 16 25 2
24 17 26 2
25 17 27 1
26 18 28 1
27 20 29 1
28 21 30 1
29 24 31 1
30 26 32 1
31 29 33 1
32 30 34 1
33 33 35 1
34 35 36 1
35 15 19 1
36 28 32 2
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