KEGG   DRUG: Anagrelide hydrochlorideHelp
Entry
D02933                      Drug                                   

Name
Anagrelide hydrochloride (USAN);
Agrylin (TN);
Xagrid (TN)
Product
  Generic
Formula
C10H7Cl2N3O. HCl
Exact mass
290.9733
Mol weight
292.549
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01507  Phosphodiesterase III inhibitor
Cyp substrate
 DG01891  CYP1A1 substrate
Remark
ATC code: 
Chemical group: 
Activity
Platelet aggregation inhibitor, Phosphodiestarase inhibitor
Target
PDE3 [HSA:5139 5140] [KO:K19021 K13296]
  Pathway
Purine metabolism
Metabolism
Enzyme: CYP1A1 [HSA:1543], CYP1A2 [HSA:1544]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX35 Anagrelide
      D02933  Anagrelide hydrochloride (USAN)
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Blood Formation Modifiers
   Anagrelide
    D02933  Anagrelide hydrochloride (USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A1
   Anagrelide
    D02933  Anagrelide hydrochloride (USAN)
Antineoplastics [br08340.html]
 D02933
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02933
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D02933
BRITE hierarchy
Other DBs
CAS: 
58579-51-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        17
            1   N1y N     9.8700   -6.3000
            2   C2y C     9.8700   -7.7000
            3   N2x N     8.6800   -8.4000
            4   C8y C     7.4200   -7.7000
            5   C8y C     7.4200   -6.3000
            6   C1x C     8.6100   -5.6000
            7   C8y C     6.2076   -5.6000
            8   C8y C     4.9951   -6.3000
            9   C8x C     4.9951   -7.7000
            10  C8x C     6.2076   -8.4000
            11  X   Cl    6.2076   -4.2000
            12  X   Cl    3.7827   -5.6000
            13  N1x N    11.2015   -8.1326
            14  C5x C    12.0244   -7.0000
            15  C1x C    11.2015   -5.8674
            16  O5x O    13.4244   -7.0000
            17  X   Cl   16.7300   -7.9800
BOND        18
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   1 1
            6     1   2 1
            7     5   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10   4 1
            12    7  11 1
            13    8  12 1
            14    2  13 1
            15   13  14 1
            16   14  15 1
            17    1  15 1
            18   14  16 2

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