KEGG   DRUG: D02934Help
Entry
D02934                      Drug                                   
Name
Anakinra (USAN/INN);
Kineret (TN)
Product
Formula
C759H1186N208O232S10
Exact mass
17246.4608
Mol weight
17257.4425
Sequence
MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG
IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW
FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
  Type
Peptide
Activity
Anti-inflammatory [nonsteroidal];
Suppressant [inflammatory bowel disease] [DS:H00630]
Remark
ATC code: 
Comment
recombinant form of human IL-1 receptor antagonist (rhuIL-1Ra) [HSA:3557] [KO:K05481]
Target
interleukin 1 receptor, type I antagonist [HSA:3554] [KO:K04386];
interleukin 1 receptor, type II antagonist [HSA:7850] [KO:K04387]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04210  Apoptosis
hsa04380  Osteoclast differentiation  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC03 Anakinra
      D02934  Anakinra (USAN/INN)
USP drug classification [BR:br08302]
 Immunological Agents
  Immune Suppressants
   Non-TNF Blockers
    Anakinra
     D02934  Anakinra (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  IL-1 receptor family
   interleukin 1 receptor, type I [HSA:3554] [KO:K04386]
    Anakinra [ATC:L04AC03]
     D02934  Anakinra (USAN/INN)
   interleukin 1 receptor, type II [HSA:7850] [KO:K04387]
    Anakinra [ATC:L04AC03]
     D02934  Anakinra (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
143090-92-0
PubChem: 
DrugBank: 
NIKKAJI: 

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