KEGG   DRUG: Ancestim
Entry
D02937                      Drug                                   
Name
Ancestim (USAN/INN);
Ancestim (genetical recombination) (JAN);
Stemgen (TN)
Formula
C1662H2650N422O512S18
Exact mass
37288.9271
Mol weight
37312.5146
Sequence
MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL
LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF
NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVAA
(Disulfide bridge: 5-90, 44-139)
  Type
Peptide
Class
Immunological agent
 DG01753  Colony stimulating factor
Remark
ATC code: L03AA12
Efficacy
Hematopoietic adjuvant (stem cell factor)
Comment
Recombinant methionyl human SCF [HSA:4254] [KO:K05461]
Treatment of anemia
Target
KIT (CD117) [HSA:3815] [KO:K05091]
  Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04640  Hematopoietic cell lineage
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AA Colony stimulating factors
     L03AA12 Ancestim
      D02937  Ancestim (USAN/INN)
Drug groups [BR:br08330]
 Immunological agent
  DG01753  Colony stimulating factor
   D02937  Ancestim
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   PDGFR family
    KIT (CD117)
     D02937  Ancestim (USAN/INN)
Other DBs
CAS: 163545-26-4
PubChem: 17397094

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Ontology (3)   
   KEGG BRITE (3)   
Drug (1)   
   KEGG DGROUP (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (7)   

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