KEGG   DRUG: D02976Help
Entry
D02976                      Drug                                   

Name
Arbutamine hydrochloride (USAN);
Genesa (TN)
Formula
C18H23NO4. HCl
Exact mass
353.1394
Mol weight
353.8405
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Stimulant [cardiac]
Remark
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
beta1-adrenergic receptor agonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor agonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor agonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA22 Arbutamine
      D02976  Arbutamine hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Arbutamine
      D02976  Arbutamine hydrochloride (USAN)
    beta1-adrenergic receptor
     Arbutamine
      D02976  Arbutamine hydrochloride (USAN)
    beta2-adrenergic receptor
     Arbutamine
      D02976  Arbutamine hydrochloride (USAN)
    beta3-adrenergic receptor
     Arbutamine
      D02976  Arbutamine hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
125251-66-3
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        24
            1   C8x C    16.1000  -14.7700
            2   C8y C    16.1000  -16.1700
            3   C8x C    14.9100  -16.8700
            4   C8y C    13.6500  -16.1700
            5   C8y C    13.6500  -14.7700
            6   C8x C    14.9100  -14.0700
            7   O1a O    12.4600  -14.0700
            8   O1a O    12.4600  -16.8700
            9   C1c C    17.2900  -16.8700
            10  C1b C    18.4800  -16.1700
            11  N1b N    19.7400  -16.8700
            12  C1b C    20.9300  -16.1700
            13  C1b C    22.1900  -16.8700
            14  C1b C    23.3800  -16.1700
            15  C1b C    24.5700  -16.8700
            16  C8y C    25.8300  -16.1700
            17  C8x C    27.0200  -16.8700
            18  C8x C    28.2100  -16.1700
            19  O1a O    17.2900  -18.2700
            20  C8x C    25.8300  -14.7700
            21  C8x C    27.0200  -14.0700
            22  C8y C    28.2100  -14.7700
            23  O1a O    29.4000  -14.0700
            24  X   Cl   31.7800  -16.6600
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     4   8 1
            9     2   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 2
            19    9  19 1 #Down
            20   16  20 2
            21   20  21 1
            22   21  22 2
            23   22  18 1
            24   22  23 1

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