KEGG   DRUG: Arbutamine hydrochlorideHelp
Entry
D02976                      Drug                                   

Name
Arbutamine hydrochloride (USAN);
Genesa (TN)
Formula
C18H23NO4. HCl
Exact mass
353.1394
Mol weight
353.8405
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
Unclassified
 DG01951  Catecholamine adrenergic receptor agonist
Remark
ATC code: 
Activity
Cardiotonic, beta-Adrenergic receptor agonist
Comment
Catecholamine derivative
Target
beta1-adrenergic receptor [HSA:153] [KO:K04141];
beta2-adrenergic receptor [HSA:154] [KO:K04142];
beta3-adrenergic receptor [HSA:155] [KO:K04143]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA22 Arbutamine
      D02976  Arbutamine hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Arbutamine
      D02976  Arbutamine hydrochloride (USAN)
    beta1-adrenergic receptor
     Arbutamine
      D02976  Arbutamine hydrochloride (USAN)
    beta2-adrenergic receptor
     Arbutamine
      D02976  Arbutamine hydrochloride (USAN)
    beta3-adrenergic receptor
     Arbutamine
      D02976  Arbutamine hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
125251-66-3
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        24
            1   C8x C    12.1800  -17.5700
            2   C8y C    12.1800  -16.1700
            3   C8x C    10.9900  -15.4700
            4   C8y C     9.7300  -16.1700
            5   C8y C     9.7300  -17.5700
            6   C8x C    10.9900  -18.2700
            7   O1a O     8.5400  -18.2700
            8   O1a O     8.5400  -15.4700
            9   C1c C    13.3700  -15.4700
            10  C1b C    14.6300  -16.1700
            11  N1b N    15.8900  -15.4700
            12  C1b C    17.0100  -16.1700
            13  C1b C    18.2700  -15.4700
            14  C1b C    19.4600  -16.1700
            15  C1b C    20.6500  -15.4700
            16  C8y C    21.9100  -16.1700
            17  C8x C    23.1000  -15.4700
            18  C8x C    24.2900  -16.1700
            19  O1a O    13.3700  -14.0700
            20  C8x C    21.9100  -17.5700
            21  C8x C    23.1000  -18.2700
            22  C8y C    24.2900  -17.5700
            23  O1a O    25.4800  -18.2700
            24  X   Cl   28.7000  -17.0800
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     4   8 1
            9     2   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 2
            19    9  19 1 #Up
            20   16  20 2
            21   20  21 1
            22   21  22 2
            23   22  18 1
            24   22  23 1

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