KEGG   DRUG: D02981Help
Entry
D02981                      Drug                                   

Name
Arformoterol tartrate (USAN);
Brovana (TN)
Product
Formula
C19H24N2O4. C4H6O6
Exact mass
494.19
Mol weight
494.4917
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-asthmatic and bronchodilator [DS:H00079]
Remark
Drug group: 
Comment
Long-acting beta-adrenoceptor agonist (LABA)
Target
beta2-adrenergic receptor agonist [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04144  Endocytosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Metabolism
Metabolism: UGT [KO:K00699]
Interaction
Drug interaction
Brite
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Arformoterol
    D02981  Arformoterol tartrate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta2-adrenergic receptor
     Arformoterol
      D02981  Arformoterol tartrate (USAN)
BRITE hierarchy
Other DBs
CAS: 
200815-49-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        35
            1   C8y C    17.4888  -18.1875
            2   C8x C    16.2298  -18.8869
            3   C8x C    17.4888  -16.7886
            4   C1c C    18.6779  -18.8869
            5   C8y C    15.0407  -18.1875
            6   C8x C    16.2298  -16.0891
            7   C1b C    19.8670  -18.1875
            8   C8y C    15.0407  -16.7886
            9   N1b N    13.8517  -18.8869
            10  N1b N    21.0560  -18.8869
            11  O1a O    13.8517  -16.0891
            12  C4a C    12.5927  -18.1875
            13  C1c C    22.3151  -18.1875
            14  O4a O    11.4036  -18.8869
            15  C1b C    23.5041  -18.8869
            16  C8y C    24.6932  -18.1875
            17  C8x C    24.6932  -16.7886
            18  C8x C    25.8823  -18.8869
            19  C8x C    25.8823  -16.0891
            20  C8x C    27.1413  -18.1875
            21  C8y C    27.1413  -16.7886
            22  O2a O    28.3303  -16.0192
            23  C1a C    29.5194  -16.7186
            24  C1a C    22.3151  -16.7886
            25  O1a O    18.6779  -20.2858
            26  O6a O    22.8666  -22.8766
            27  C6a C    24.0556  -22.1771
            28  C1c C    25.3147  -22.8766
            29  C1c C    26.5037  -22.1771
            30  C6a C    27.6928  -22.8766
            31  O6a O    24.0556  -20.7782
            32  O6a O    28.9518  -22.1771
            33  O6a O    27.6928  -24.2755
            34  O1a O    25.3147  -24.2755
            35  O1a O    26.5037  -20.7782
BOND        35
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     7  10 1
            10    8  11 1
            11    9  12 1
            12   10  13 1
            13   12  14 2
            14   13  15 1
            15   15  16 1
            16   16  17 2
            17   16  18 1
            18   17  19 1
            19   18  20 2
            20   19  21 2
            21   21  22 1
            22   22  23 1
            23    6   8 1
            24   20  21 1
            25   13  24 1 #Down
            26    4  25 1 #Down
            27   26  27 1
            28   27  28 1
            29   28  29 1
            30   29  30 1
            31   27  31 2
            32   30  32 1
            33   30  33 2
            34   28  34 1 #Up
            35   29  35 1 #Up

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