KEGG   DRUG: D02983Help
Entry
D02983                      Drug                                   

Name
Argipressin tannate (USAN);
Pitressin tannate (TN)
Product
  Other
Formula
C46H65N15O12S2
Exact mass
1083.4379
Mol weight
1084.2316
Structure
Mol fileKCF fileDB searchJmolKegDraw
Sequence
Cys Tyr Phe Gln Asn Cys Pro Arg Gly-NH2 (Disulfide bridge: 1-6)
  Type
Peptide
Activity
Antidiuretic
Remark
Same as: 
ATC code: 
Comment
Vasopressin derivative
Target
arginine vasopressin receptor 1A (AVPR1A) agonist [HSA:552] [KO:K04226];
arginine vasopressin receptor 1B (AVPR1B) agonist [HSA:553] [KO:K04227];
arginine vasopressin receptor 2 (AVPR2) agonist [HSA:554] [KO:K04228]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04962  Vasopressin-regulated water reabsorption  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01B POSTERIOR PITUITARY LOBE HORMONES
    H01BA Vasopressin and analogues
     H01BA06 Argipressin
      D02983  Argipressin tannate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Vasopressin
    arginine vasopressin receptor 1A (AVPR1A)
     Argipressin
      D02983  Argipressin tannate (USAN)
    arginine vasopressin receptor 1B (AVPR1B)
     Argipressin
      D02983  Argipressin tannate (USAN)
    arginine vasopressin receptor 2 (AVPR2)
     Argipressin
      D02983  Argipressin tannate (USAN)
BRITE hierarchy
Other DBs
CAS: 
113-79-1
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        75
            1   N1y N    11.5248  -19.2026
            2   C1y C    11.9435  -20.4587
            3   C5a C    11.5248  -17.3165
            4   C1x C    10.1989  -19.2024
            5   C5a C    13.0601  -21.1566
            6   C1x C    10.8967  -21.2962
            7   C1y C    12.6414  -16.6187
            8   O5a O    10.3385  -16.6187
            9   C1x C     9.7802  -20.5285
            10  N1b N    14.1766  -20.4587
            11  O5a O    13.0601  -22.4127
            12  N1x N    12.6414  -15.2927
            13  C1x C    13.7579  -17.3165
            14  C1c C    15.3630  -21.1566
            15  C5x C    13.7579  -14.6647
            16  S3x S    14.9443  -16.6187
            17  C5a C    15.3630  -22.7627
            18  C1b C    16.4795  -20.4587
            19  C1y C    13.7579  -13.3388
            20  O5x O    14.9443  -15.2927
            21  S3x S    16.0608  -17.3165
            22  N1b N    16.4795  -23.4606
            23  O5a O    14.1766  -23.4606
            24  C1b C    17.5961  -21.1566
            25  N1x N    12.6414  -12.6409
            26  C1b C    14.9443  -12.6409
            27  C1x C    17.1774  -16.6187
            28  C1b C    17.5961  -22.7627
            29  C1b C    18.7824  -20.4587
            30  C5x C    12.6414  -10.8948
            31  C5a C    16.0608  -13.3388
            32  C1y C    18.3637  -17.3165
            33  N1b N    19.8990  -21.1566
            34  C1y C    14.6651   -9.7772
            35  O5x O    11.5248  -10.1970
            36  N1a N    17.1774  -12.6409
            37  O5a O    16.0608  -14.6647
            38  C5x C    19.4803  -16.6187
            39  N1a N    18.3637  -18.5726
            40  N1x N    16.4795  -10.8948
            41  C1b C    14.6651   -8.1023
            42  N1x N    20.5968  -17.3165
            43  O5x O    19.4803  -15.2927
            44  C5x C    18.3637   -9.7772
            45  C1b C    13.5486   -7.4045
            46  C1y C    21.7831  -16.6187
            47  C1y C    20.6666  -10.8948
            48  O5x O    18.3637   -8.4513
            49  C5a C    12.3622   -8.0326
            50  C1b C    22.8997  -17.3165
            51  C5x C    21.7831  -15.2927
            52  C1b C    21.9227   -9.8470
            53  N1x N    20.6666  -14.2447
            54  N1a N    11.2457   -7.4045
            55  O5a O    12.3622   -9.3585
            56  C8y C    24.0163  -16.6187
            57  O5x O    22.8997  -14.6647
            58  C8y C    23.1091  -10.4750
            59  C8x C    25.1328  -17.2467
            60  C8x C    24.0163  -15.2927
            61  C8x C    23.1091  -11.8009
            62  C8x C    24.2256   -9.7772
            63  C8x C    26.3191  -16.6187
            64  C8x C    25.1328  -14.6647
            65  C8x C    24.2256  -12.4290
            66  C8x C    25.3422  -10.4750
            67  C8y C    26.3191  -15.2927
            68  C8x C    25.3422  -11.8009
            69  O1a O    27.4357  -14.6647
            70  C2c C    21.0853  -20.3890
            71  N1a N    22.3414  -21.1566
            72  N2a N    21.0853  -19.0631
            73  C5a C    18.8522  -23.5303
            74  N1a N    20.0385  -22.8325
            75  O5a O    18.8522  -24.9260
BOND        78
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1 #Down
            5     2   6 1
            6     7   3 1 #Up
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    7  12 1
            12    7  13 1
            13   10  14 1
            14   12  15 1
            15   13  16 1
            16   14  17 1 #Up
            17   14  18 1
            18   15  19 1
            19   15  20 2
            20   16  21 1
            21   17  22 1
            22   17  23 2
            23   18  24 1
            24   19  25 1
            25   19  26 1 #Up
            26   21  27 1
            27   22  28 1
            28   24  29 1
            29   25  30 1
            30   26  31 1
            31   27  32 1
            32   29  33 1
            33   30  34 1
            34   30  35 2
            35   31  36 1
            36   31  37 2
            37   32  38 1
            38   32  39 1 #Up
            39   34  40 1
            40   34  41 1 #Down
            41   38  42 1
            42   38  43 2
            43   40  44 1
            44   41  45 1
            45   42  46 1
            46   44  47 1
            47   44  48 2
            48   45  49 1
            49   46  50 1 #Down
            50   46  51 1
            51   47  52 1 #Down
            52   47  53 1
            53   49  54 1
            54   49  55 2
            55   50  56 1
            56   51  57 2
            57   52  58 1
            58   56  59 2
            59   56  60 1
            60   58  61 2
            61   58  62 1
            62   59  63 1
            63   60  64 2
            64   61  65 1
            65   62  66 2
            66   63  67 2
            67   65  68 2
            68   67  69 1
            69    6   9 1
            70   51  53 1
            71   64  67 1
            72   66  68 1
            73   33  70 1
            74   70  71 1
            75   70  72 2
            76   28  73 1
            77   73  74 1
            78   73  75 2

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