KEGG   DRUG: BesonprodilHelp
Entry
D03100                      Drug                                   

Name
Besonprodil (USAN)
Formula
C21H23FN2O3S
Exact mass
402.1413
Mol weight
402.4823
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01498  NMDA receptor antagonist
Unclassified
 DG01967  Antiparkinson agent
Activity
Antiparkinsonian, NMDA receptor antagonist
Comment
Treatment of Parkinson's disease
Target
GRIN2B (NMDAR2B) [HSA:2904] [KO:K05210]
  Pathway
Neuroactive ligand-receptor interaction
Long-term potentiation
Glutamatergic synapse
Alzheimer's disease
Interaction
Drug interaction
Structure map
Antiparkinsonian agents
N-Metyl-D-aspartic acid receptor antagonists
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), NMDA
    N-methyl-D-aspartate 2B receptor
     Besonprodil
      D03100  Besonprodil (USAN)
BRITE hierarchy
Other DBs
CAS: 
253450-09-8
PubChem: 
LigandBox: 
KCF data Show

ATOM        28
            1   C8x C    30.7300  -14.6300
            2   C8y C    30.7300  -16.0300
            3   C8x C    31.9900  -16.7300
            4   C8y C    33.2500  -16.0300
            5   C8y C    33.2500  -14.6300
            6   C8x C    31.9900  -13.8600
            7   O7x O    34.5800  -16.4500
            8   C8y C    35.3500  -15.3300
            9   N4x N    34.5800  -14.1400
            10  O6a O    36.7500  -15.3300
            11  S4a S    29.5400  -16.6600
            12  C1b C    28.3500  -16.0300
            13  O3c O    29.5400  -18.1300
            14  C1b C    27.1600  -16.6600
            15  N1y N    25.9700  -16.0300
            16  C1x C    24.7800  -16.6600
            17  C1x C    23.5900  -15.9600
            18  C1y C    23.5900  -14.5600
            19  C1x C    24.7800  -13.8600
            20  C1x C    25.9700  -14.5600
            21  C1b C    22.3300  -13.8600
            22  C8y C    21.1400  -14.5600
            23  C8x C    21.1400  -16.0300
            24  C8x C    19.8800  -16.6600
            25  C8y C    18.6900  -15.9600
            26  C8x C    18.6900  -14.5600
            27  C8x C    19.8800  -13.8600
            28  X   F    17.5000  -16.6600
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 2
            12    2  11 1
            13   11  12 1
            14   11  13 2
            15   12  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   15  20 1
            23   18  21 1
            24   21  22 1
            25   22  23 2
            26   23  24 1
            27   24  25 2
            28   25  26 1
            29   26  27 2
            30   22  27 1
            31   25  28 1

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