KEGG   DRUG: D03100Help
Entry
D03100                      Drug                                   

Name
Besonprodil (USAN)
Formula
C21H23FN2O3S
Exact mass
402.1413
Mol weight
402.4823
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of Parkinson's disease [NMDA receptor antagonist] [DS:H00057]
Target
N-methyl-D-aspartate receptor (NMDA) NR2B-selective antagonist [HSA:2904] [KO:K05210]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer's disease  
 
Interaction
Drug interaction
Structure map
Antiparkinsonian agents
N-Metyl-D-aspartic acid receptor antagonists
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), NMDA
    N-methyl-D-aspartate 2B receptor
     Besonprodil
      D03100  Besonprodil (USAN)
BRITE hierarchy
Other DBs
CAS: 
253450-09-8
PubChem: 
LigandBox: 
KCF data Show

ATOM        28
            1   C8x C    30.7300  -14.6300
            2   C8y C    30.7300  -16.0300
            3   C8x C    31.9900  -16.7300
            4   C8y C    33.2500  -16.0300
            5   C8y C    33.2500  -14.6300
            6   C8x C    31.9900  -13.8600
            7   O7x O    34.5800  -16.4500
            8   C8y C    35.3500  -15.3300
            9   N4x N    34.5800  -14.1400
            10  O6a O    36.7500  -15.3300
            11  S4a S    29.5400  -16.6600
            12  C1b C    28.3500  -16.0300
            13  O3c O    29.5400  -18.1300
            14  C1b C    27.1600  -16.6600
            15  N1y N    25.9700  -16.0300
            16  C1x C    24.7800  -16.6600
            17  C1x C    23.5900  -15.9600
            18  C1y C    23.5900  -14.5600
            19  C1x C    24.7800  -13.8600
            20  C1x C    25.9700  -14.5600
            21  C1b C    22.3300  -13.8600
            22  C8y C    21.1400  -14.5600
            23  C8x C    21.1400  -16.0300
            24  C8x C    19.8800  -16.6600
            25  C8y C    18.6900  -15.9600
            26  C8x C    18.6900  -14.5600
            27  C8x C    19.8800  -13.8600
            28  X   F    17.5000  -16.6600
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 2
            12    2  11 1
            13   11  12 1
            14   11  13 2
            15   12  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   15  20 1
            23   18  21 1
            24   21  22 1
            25   22  23 2
            26   23  24 1
            27   24  25 2
            28   25  26 1
            29   26  27 2
            30   22  27 1
            31   25  28 1

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