| Entry |
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| Name |
Bortezomib (JAN/USAN/INN);
Velcade (TN)
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| Product |
|
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| Formula |
C19H25BN4O4
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| Exact mass |
384.1969
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| Mol weight |
384.2372
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| Structure |
     |
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| Activity |
Treatment of multiple cancers, including multiple myeloma, chronic lymphocytic leukemia, non-Hodgkins lymphoma, and pancreatic, colon, lung, and prostate cancers [proteasome inhibitor]
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| Remark |
Therapeutic category: ATC code: |
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| Target |
proteasome subunit beta type-1 inhibitor [HSA: 5689] [KO: K02732]; proteasome subunit beta type-5 inhibitor [HSA: 5693] [KO: K02737] |
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| Pathway |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP2C19 [HSA: 1557], CYP1A2 [HSA: 1544]
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| Interaction |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
429 Miscellaneous
4291 Other Antitumors
D03150 Bortezomib (JAN/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01X OTHER ANTINEOPLASTIC AGENTS
L01XX Other antineoplastic agents
L01XX32 Bortezomib
D03150 Bortezomib (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases
proteasome subunit beta type-1 (PSMB1) [HSA:5689] [KO:K02732]
Bortezomib [ATC:L01XX32]
D03150 Bortezomib (JAN/USAN/INN)
proteasome subunit beta type-5 (PSMB5) [HSA:5693] [KO:K02737]
Bortezomib [ATC:L01XX32]
D03150 Bortezomib (JAN/USAN/INN)
Antineoplastics [BR:br08308]
Molecularly targeted agents
Proteosome inhibitor
Bortezomib [ATC:L01XX32]
D03150 Bortezomib (JAN/USAN/INN)
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| Other DBs |
CAS: 179324-69-7 PubChem: DrugBank: PDB-CCD: NIKKAJI: |
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| KCF data |
ATOM 28
1 N1b N 22.6554 -16.2029
2 C1c C 23.8603 -15.5194
3 C8x C 17.8708 -16.2029
4 C8x C 17.8708 -17.5889
5 N5x N 19.0679 -18.2854
6 C8x C 20.2651 -17.5889
7 C8y C 20.2651 -16.2029
8 N5x N 19.0679 -15.5134
9 C5a C 21.4576 -15.5134
10 O5a O 21.4564 -14.1276
11 C5a C 25.0492 -16.2179
12 N1b N 26.2724 -15.5238
13 C1c C 27.4532 -16.2173
14 C1b C 28.6374 -15.5453
15 C1c C 29.7998 -16.2280
16 C1a C 30.9930 -15.5506
17 C1a C 29.7895 -17.6043
18 O5a O 25.0388 -17.6038
19 C1b C 23.8705 -14.1451
20 C8y C 25.0967 -13.4488
21 C8x C 26.2767 -14.1418
22 C8x C 27.4803 -13.4586
23 C8x C 27.4905 -12.0748
24 C8x C 26.3105 -11.3818
25 C8x C 25.1069 -12.0650
26 Z B 27.4430 -18.1578
27 O1a O 26.2291 -18.8468
28 O1a O 28.6261 -18.8527
BOND 29
1 3 4 2
2 4 5 1
3 5 6 2
4 6 7 1
5 7 8 2
6 8 3 1
7 7 9 1
8 9 1 1
9 2 1 1
10 9 10 2
11 2 11 1
12 11 12 1
13 12 13 1
14 13 14 1
15 14 15 1
16 15 16 1
17 15 17 1
18 11 18 2
19 19 20 1
20 20 21 2
21 21 22 1
22 22 23 2
23 23 24 1
24 24 25 2
25 20 25 1
26 2 19 1 #Up
27 26 27 1
28 26 28 1
29 13 26 1 #Up
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