KEGG   DRUG: BortezomibHelp
Entry
D03150                      Drug                                   

Name
Bortezomib (JAN/USAN/INN);
Velcade (TN)
Product
Formula
C19H25BN4O4
Exact mass
384.1969
Mol weight
384.2372
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A4 substrate
Remark
Therapeutic category: 
ATC code: 
Activity
Antineoplastic, Proteasome inhibitor
Comment
Treatment of multiple cancers, including multiple myeloma, chronic lymphocytic leukemia, non-Hodgkins lymphoma, and pancreatic, colon, lung, and prostate cancers
Target
proteasome subunit beta type-1 inhibitor [HSA:5689] [KO:K02732];
proteasome subunit beta type-5 inhibitor [HSA:5693] [KO:K02737]
  Pathway
Proteasome
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C19 [HSA:1557], CYP1A2 [HSA:1544]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX32 Bortezomib
      D03150  Bortezomib (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D03150  Bortezomib (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   proteasome subunit beta type-1 (PSMB1)
    Bortezomib
     D03150  Bortezomib (JAN/USAN/INN)
   proteasome subunit beta type-5 (PSMB5)
    Bortezomib
     D03150  Bortezomib (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Bortezomib
    D03150  Bortezomib (JAN/USAN/INN)
  CYP2C19
   Bortezomib
    D03150  Bortezomib (JAN/USAN/INN)
  CYP3A4
   Bortezomib
    D03150  Bortezomib (JAN/USAN/INN)
Antineoplastics [br08340.html]
 D03150
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D03150
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D03150
BRITE hierarchy
Other DBs
CAS: 
179324-69-7
PubChem: 
DrugBank: 
PDB-CCD: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   N1b N    22.6554  -16.2029
            2   C1c C    23.8603  -15.5194
            3   C8x C    17.8708  -16.2029
            4   C8x C    17.8708  -17.5889
            5   N5x N    19.0679  -18.2854
            6   C8x C    20.2651  -17.5889
            7   C8y C    20.2651  -16.2029
            8   N5x N    19.0679  -15.5134
            9   C5a C    21.4576  -15.5134
            10  O5a O    21.4564  -14.1276
            11  C5a C    25.0492  -16.2179
            12  N1b N    26.2724  -15.5238
            13  C1c C    27.4532  -16.2173
            14  C1b C    28.6374  -15.5453
            15  C1c C    29.7998  -16.2280
            16  C1a C    30.9930  -15.5506
            17  C1a C    29.7895  -17.6043
            18  O5a O    25.0388  -17.6038
            19  C1b C    23.8705  -14.1451
            20  C8y C    25.0967  -13.4488
            21  C8x C    26.2767  -14.1418
            22  C8x C    27.4803  -13.4586
            23  C8x C    27.4905  -12.0748
            24  C8x C    26.3105  -11.3818
            25  C8x C    25.1069  -12.0650
            26  Z   B    27.4430  -18.1578
            27  O1a O    26.2291  -18.8468
            28  O1a O    28.6261  -18.8527
BOND        29
            1     3   4 2
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     8   3 1
            7     7   9 1
            8     9   1 1
            9     2   1 1
            10    9  10 2
            11    2  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   15  17 1
            18   11  18 2
            19   19  20 1
            20   20  21 2
            21   21  22 1
            22   22  23 2
            23   23  24 1
            24   24  25 2
            25   20  25 1
            26    2  19 1 #Up
            27   26  27 1
            28   26  28 1
            29   13  26 1 #Up

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