KEGG   DRUG: D03150Help
Entry
D03150                      Drug                                   

Name
Bortezomib (JAN/USAN/INN);
Velcade (TN)
Product
Formula
C19H25BN4O4
Exact mass
384.1969
Mol weight
384.2372
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of multiple cancers, including multiple myeloma, chronic lymphocytic leukemia, non-Hodgkins lymphoma, and pancreatic, colon, lung, and prostate cancers [proteasome inhibitor]
Remark
Therapeutic category: 
ATC code: 
Target
proteasome subunit beta type-1 inhibitor [HSA:5689] [KO:K02732];
proteasome subunit beta type-5 inhibitor [HSA:5693] [KO:K02737]
  Pathway
hsa03050  Proteasome  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C19 [HSA:1557], CYP1A2 [HSA:1544]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX32 Bortezomib
      D03150  Bortezomib (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D03150  Bortezomib (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   proteasome subunit beta type-1 (PSMB1)
    Bortezomib
     D03150  Bortezomib (JAN/USAN/INN)
   proteasome subunit beta type-5 (PSMB5)
    Bortezomib
     D03150  Bortezomib (JAN/USAN/INN)
Antineoplastics [BR:br08308]
 Molecularly targeted agents
  Proteosome inhibitor
   Bortezomib
    D03150  Bortezomib (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Bortezomib
    D03150  Bortezomib (JAN/USAN/INN)
  CYP2C19
   Bortezomib
    D03150  Bortezomib (JAN/USAN/INN)
  CYP3A4
   Bortezomib
    D03150  Bortezomib (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
179324-69-7
PubChem: 
DrugBank: 
PDB-CCD: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   N1b N    22.6554  -16.2029
            2   C1c C    23.8603  -15.5194
            3   C8x C    17.8708  -16.2029
            4   C8x C    17.8708  -17.5889
            5   N5x N    19.0679  -18.2854
            6   C8x C    20.2651  -17.5889
            7   C8y C    20.2651  -16.2029
            8   N5x N    19.0679  -15.5134
            9   C5a C    21.4576  -15.5134
            10  O5a O    21.4564  -14.1276
            11  C5a C    25.0492  -16.2179
            12  N1b N    26.2724  -15.5238
            13  C1c C    27.4532  -16.2173
            14  C1b C    28.6374  -15.5453
            15  C1c C    29.7998  -16.2280
            16  C1a C    30.9930  -15.5506
            17  C1a C    29.7895  -17.6043
            18  O5a O    25.0388  -17.6038
            19  C1b C    23.8705  -14.1451
            20  C8y C    25.0967  -13.4488
            21  C8x C    26.2767  -14.1418
            22  C8x C    27.4803  -13.4586
            23  C8x C    27.4905  -12.0748
            24  C8x C    26.3105  -11.3818
            25  C8x C    25.1069  -12.0650
            26  Z   B    27.4430  -18.1578
            27  O1a O    26.2291  -18.8468
            28  O1a O    28.6261  -18.8527
BOND        29
            1     3   4 2
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     8   3 1
            7     7   9 1
            8     9   1 1
            9     2   1 1
            10    9  10 2
            11    2  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   15  17 1
            18   11  18 2
            19   19  20 1
            20   20  21 2
            21   21  22 1
            22   22  23 2
            23   23  24 1
            24   24  25 2
            25   20  25 1
            26    2  19 1 #Up
            27   26  27 1
            28   26  28 1
            29   13  26 1 #Up

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