KEGG   DRUG: D03203Help
Entry
D03203                      Drug                                   

Name
Abatacept (genetical recombination) (JAN);
Abatacept (USAN/INN);
Orencia (TN)
Product
Sequence
MGVLLTQRTL LSLVLALLFP SMASMAMHVA QPAVVLASSR GIASFVCEYA SPGKATEVRV
TVLRQADSQV TEVCAATYMM GNELTFLDDS ICTGTSSGNQ VNLTIQGLRA MDTGLYICKV
ELMYPPPYYL GIGNGTQIYV IDPEPCPDSD QEPKSSDKTH TSPPSPAPEL LGGSSVFLFP
PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS
VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS
LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS
CSVMHEALHN HYTQKSLSLS PGK (Dimer: 146)
  Type
Peptide
Activity
Treatment of autoimmune diseases such as rheumatoid arthritis [selective co-stimulation modulator;
binds to the B7 family of molecules expressed on antigen-presenting cells (APC)] [DS:H00630]
Remark
Therapeutic category: 
ATC code: 
Comment
Abatacept is a fusion protein composed of an immunoglobulin fused to the extracellular domain of CTLA-4.
Abatacept binds to CD80/86, to inhibit the CD28 costimulatory signal.
Target
CD80/86 agonist [HSA:941 942] [KO:K05412 K05413]
  Pathway
hsa04514  Cell adhesion molecules (CAMs)
hsa04620  Toll-like receptor signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa05323  Rheumatoid arthritis  
 
Interaction
Drug interaction
Structure map
Antirheumatics - DMARDs and biological agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AA Selective immunosuppressants
     L04AA24 Abatacept
      D03203  Abatacept (genetical recombination) (JAN); Abatacept (USAN/INN)
USP drug classification [BR:br08302]
 Immunological Agents
  Immune Suppressants
   Abatacept
    D03203  Abatacept (genetical recombination) (JAN); Abatacept (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D03203  Abatacept (genetical recombination) (JAN); Abatacept (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Others
  Cellular antigens
   CD80/86
    Abatacept
     D03203  Abatacept (genetical recombination) (JAN); Abatacept (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
332348-12-6
PubChem: 
DrugBank: 

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