KEGG   DRUG: D03208Help
Entry
D03208                      Drug                                   

Name
Aliskiren (USAN/INN);
Rasilez (TN)
Formula
C30H53N3O6
Exact mass
551.3934
Mol weight
551.7583
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of essential hypertension [renin inhibitor]
Remark
ATC code: 
Drug group: 
Target
renin inhibitor [HSA:5972] [KO:K01380]
  Pathway
hsa04614  Renin-angiotensin system  
 
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Drug interaction
Structure map
Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09X OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
    C09XA Renin-inhibitors
     C09XA02 Aliskiren
      D03208  Aliskiren (USAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Cardiovascular Agents, Other
   Aliskiren
    D03208  Aliskiren (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   renin
    Aliskiren
     D03208  Aliskiren (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
173334-57-1
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        39
            1   C8x C    25.2686  -13.2653
            2   C8y C    25.2686  -14.6393
            3   C8x C    26.4366  -15.3263
            4   C8y C    27.6731  -14.6393
            5   C8y C    27.6731  -13.2653
            6   C8x C    26.4366  -12.5784
            7   O2a O    28.8410  -12.5784
            8   C1a C    30.0089  -13.2653
            9   C1b C    24.1008  -15.3263
            10  O2a O    28.8573  -15.3361
            11  C1b C    30.0445  -14.6636
            12  C1b C    31.2674  -15.3263
            13  C1b C    32.4573  -14.6393
            14  O2a O    33.6472  -15.3263
            15  C1a C    34.8371  -14.6393
            16  C1c C    22.9109  -14.6393
            17  C1b C    21.7210  -15.3263
            18  C1c C    20.5311  -14.6393
            19  C1c C    19.3413  -15.3263
            20  C1b C    18.1514  -14.6393
            21  C1c C    16.9615  -15.3263
            22  C5a C    15.7716  -14.6393
            23  N1b N    14.5818  -15.3263
            24  C1b C    13.3919  -14.6393
            25  C1d C    12.2019  -15.3263
            26  C5a C    11.0121  -14.6393
            27  N1a N     9.8223  -15.3263
            28  O5a O    15.7716  -13.2654
            29  C1a C    11.0121  -16.0132
            30  C1a C    13.3919  -16.0132
            31  O5a O    11.0121  -13.2657
            32  C1c C    16.9615  -17.1124
            33  C1a C    15.7676  -17.8016
            34  C1a C    18.1475  -17.7971
            35  O1a O    19.3416  -16.7107
            36  N1a N    20.5306  -13.2152
            37  C1c C    22.9109  -12.7159
            38  C1a C    24.1173  -12.0193
            39  C1a C    21.7375  -12.0384
BOND        39
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     2   9 1
            10    4  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16    9  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   26  27 1
            28   22  28 2
            29   25  29 1
            30   25  30 1
            31   26  31 2
            32   32  33 1
            33   32  34 1
            34   21  32 1 #Up
            35   19  35 1 #Up
            36   18  36 1 #Up
            37   37  38 1
            38   37  39 1
            39   16  37 1 #Up

» Japanese version   » Back

DBGET integrated database retrieval system