KEGG   DRUG: Insulin glargineHelp
Entry
D03250                      Drug                                   

Name
Insulin glargine (USAN/INN);
Insulin glargine (genetical recombination) (JP17);
Insulin glargine (genetical recombination) injection (JP17);
Insulin glargine (genetical recombination [Insulin glargin biosimilar 1] (JAN);
Insulin glargine (genetical recombination) [Insulin glargin biosimilar 2] (JAN);
Lantus (TN)
Product
Formula
C267H404N72O78S6
Exact mass
6058.8184
Mol weight
6062.8903
Sequence
(A chain) Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr
Gln Leu Glu Asn Tyr Cys Gly (Disulfide bridge: 6-11)
(B chain) Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala
Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr
Arg Arg (Disulfide bridge: A7-B7; A20-B19)
  Type
Peptide
Class
Antidiabetic agent
 DG01636  Insulin and analogue
  DG01801  Insulin analogue
   DG01797  Insulin analogue, long-acting
Cyp inducer
 DG01637  CYP1A2 inducer
Remark
Therapeutic category: 
ATC code: 
Activity
Antidiabetic [basal insulin analog]
Target
insulin receptor [HSA:3643] [KO:K04527]
  Pathway
Insulin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Interaction
CYP induction: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10A INSULINS AND ANALOGUES
    A10AE Insulins and analogues for injection, long-acting
     A10AE04 Insulin glargine
      D03250  Insulin glargine (USAN/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Insulins
   Insulin glargine
    D03250  Insulin glargine (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2492  Pancreatic hormones
     D03250  Insulin glargine (USAN/INN); Insulin glargine (genetical recombination) (JP17); Insulin glargine (genetical recombination) injection (JP17); Insulin glargine (genetical recombination [Insulin glargin biosimilar 1] (JAN); Insulin glargine (genetical recombination) [Insulin glargin biosimilar 2] (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class II (Insulin receptor family)
    insulin receptor
     Insulin glargine
      D03250  Insulin glargine (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inducers
  CYP1A2
   Insulin glargine
    D03250  Insulin glargine (USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D03250  Insulin glargine (genetical recombination)
  D03250  Insulin glargine (genetical recombination) injection
Antidiabetics [br08361.html]
 D03250
BRITE hierarchy
Other DBs
CAS: 
160337-95-1
PubChem: 
DrugBank: 
NIKKAJI: 

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