KEGG   DRUG: D03250Help
Entry
D03250                      Drug                                   

Name
Insulin glargine (genetical recombination) (JP16);
Insulin glargine (genetical recombination) injection (JP16);
Insulin glargine (genetical recombination) [Insulin glargin biosimilar 1] (JAN);
Insulin glargine (USAN/INN);
Lantus (TN)
Product
Formula
C267H404N72O78S6
Exact mass
6058.8184
Mol weight
6062.8903
Sequence
(A chain) Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr
Gln Leu Glu Asn Tyr Cys Gly (Disulfide bridge: 6-11)
(B chain) Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala
Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr
Arg Arg (Disulfide bridge: A7-B7; A20-B19)
  Type
Peptide
Activity
Antidiabetic [basal insulin analog] [DS:H00408 H00409]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
insulin receptor agonist [HSA:3643] [KO:K04527]
  Pathway
hsa04910  Insulin signaling pathway
hsa04930  Type II diabetes mellitus
hsa04960  Aldosterone-regulated sodium reabsorption  
 
Interaction
CYP induction: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10A INSULINS AND ANALOGUES
    A10AE Insulins and analogues for injection, long-acting
     A10AE04 Insulin glargine
      D03250  Insulin glargine (genetical recombination) (JP16); Insulin glargine (genetical recombination) injection (JP16); Insulin glargine (genetical recombination) [Insulin glargin biosimilar 1] (JAN); Insulin glargine (USAN/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Insulins
   Insulin glargine
    D03250  Insulin glargine (genetical recombination) (JAN); Insulin glargine (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2492  Pancreatic hormones
     D03250  Insulin glargine (genetical recombination) (JP16); Insulin glargine (genetical recombination) injection (JP16); Insulin glargine (genetical recombination) [Insulin glargin biosimilar 1] (JAN); Insulin glargine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class II (Insulin receptor family)
    insulin receptor
     Insulin glargine
      D03250  Insulin glargine (genetical recombination) (JAN); Insulin glargine (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Inducers
  CYP1A2
   Insulin glargine
    D03250  Insulin glargine (genetical recombination) (JAN); Insulin glargine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
160337-95-1
PubChem: 
DrugBank: 
NIKKAJI: 

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