KEGG   DRUG: D03274Help
Entry
D03274                      Drug                                   

Name
Chlorpromazine hibenzate (JAN);
Contomin (TN)
Formula
C17H19ClN2S. C14H10O4
Exact mass
560.1537
Mol weight
561.091
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotic
Remark
ATC code: 
Drug group: 
Target
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
H1-receptor antagonist [HSA:3269] [KO:K04149];
alpha2-adrenergic receptor antagonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145];
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antipsychotics
Phenothiazines
Histamine H1 receptor antagonists
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AA Phenothiazines with aliphatic side-chain
     N05AA01 Chlorpromazine
      D03274  Chlorpromazine hibenzate (JAN)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Chlorpromazine
    D03274  Chlorpromazine hibenzate (JAN)
 Antipsychotics
  1st Generation/Typical
   Chlorpromazine
    D03274  Chlorpromazine hibenzate (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Chlorpromazine
      D03274  Chlorpromazine hibenzate (JAN)
   Adrenaline
    alpha2-adrenergic receptor
     Chlorpromazine
      D03274  Chlorpromazine hibenzate (JAN)
   Dopamine
    dopamine D2-receptor
     Chlorpromazine
      D03274  Chlorpromazine hibenzate (JAN)
   Histamine
    H1-receptor
     Chlorpromazine
      D03274  Chlorpromazine hibenzate (JAN)
   Serotonin
    5-HT2-receptor
     Chlorpromazine
      D03274  Chlorpromazine hibenzate (JAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Chlorpromazine
    D03274  Chlorpromazine hibenzate (JAN)
 Inhbitors
  CYP2D6
   Chlorpromazine
    D03274  Chlorpromazine hibenzate (JAN)
BRITE hierarchy
Other DBs
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        39
            1   C8x C    18.0665  -18.4415
            2   C8x C    18.0665  -19.8441
            3   C8x C    19.2811  -20.5454
            4   C8y C    20.4959  -19.8441
            5   C8y C    20.4959  -18.4415
            6   C8x C    19.2811  -17.7402
            7   S2x S    21.7106  -20.5454
            8   C8y C    22.9253  -19.8441
            9   C8y C    22.9253  -18.4415
            10  N4y N    21.7106  -17.7402
            11  C8x C    24.1401  -20.5454
            12  C8x C    25.3547  -19.8441
            13  C8y C    25.3547  -18.4415
            14  C8x C    24.1401  -17.7402
            15  C1b C    21.7106  -16.3375
            16  C1b C    22.9274  -15.6350
            17  C1b C    24.1261  -16.3273
            18  N1c N    25.3152  -15.6408
            19  C1a C    26.5089  -16.3303
            20  C1a C    25.3154  -14.2338
            21  X   Cl   26.5735  -17.7379
            22  C8x C    29.6100  -18.3400
            23  C8y C    29.6100  -19.7400
            24  C8x C    30.8224  -20.4400
            25  C8x C    32.0349  -19.7400
            26  C8y C    32.0349  -18.3400
            27  C8x C    30.8224  -17.6400
            28  C8x C    34.4597  -19.7400
            29  C8y C    34.4597  -18.3400
            30  C5a C    33.2473  -17.6400
            31  C8x C    35.6722  -20.4400
            32  C8x C    36.8846  -19.7400
            33  C8x C    36.8846  -18.3400
            34  C8y C    35.6722  -17.6400
            35  O1a O    28.3976  -20.4400
            36  O5a O    33.2473  -16.2400
            37  C6a C    35.6722  -16.2403
            38  O6a O    36.9054  -15.5280
            39  O6a O    34.4806  -15.5522
BOND        42
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   10  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   18  20 1
            23   13  21 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   22  27 1
            30   28  29 1
            31   29  30 1
            32   26  30 1
            33   28  31 2
            34   31  32 1
            35   32  33 2
            36   33  34 1
            37   29  34 2
            38   23  35 1
            39   30  36 2
            40   34  37 1
            41   37  38 1
            42   37  39 2

» Japanese version   » Back

DBGET integrated database retrieval system