KEGG   DRUG: Profenamine hibenzateHelp
Entry
D03276                      Drug                                   

Name
Profenamine hibenzate (JAN);
Parkin (TN)
Formula
C19H24N2S. C14H10O4
Exact mass
554.2239
Mol weight
554.6991
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
 DG01745  Anticholinergic antiparkinson agent
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antiparkinsonian
  Disease
Parkinsonism [DS:H01600]
Comment
Phenothiazine derivative
Target
muscarinic cholinergic receptor [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Salivary secretion
Gastric acid secretion
Interaction
Drug interaction
Structure map
Phenothiazines
Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AA Tertiary amines
     N04AA05 Profenamine
      D03276  Profenamine hibenzate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1163  Profenamines
     D03276  Profenamine hibenzate (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Profenamine
      D03276  Profenamine hibenzate (JAN)
Neurological agents [br08367.html]
 Antiparkinson agents
  D03276
BRITE hierarchy
Other DBs
PubChem: 
LigandBox: 
KCF data Show

ATOM        40
            1   C8y C     4.2000  -19.3900
            2   C8y C     4.2000  -20.7900
            3   S2x S     5.3900  -21.4900
            4   C8y C     6.6500  -20.7900
            5   C8y C     6.6500  -19.3900
            6   N1y N     5.3900  -18.6900
            7   C8x C     7.8400  -21.4900
            8   C8x C     9.0300  -20.7900
            9   C8x C     9.0300  -19.3900
            10  C8x C     7.8400  -18.6900
            11  C8x C     3.0100  -18.6900
            12  C8x C     1.7500  -19.3900
            13  C8x C     1.7500  -20.7900
            14  C8x C     3.0100  -21.4900
            15  C1b C     5.3900  -17.2900
            16  C1c C     6.6500  -16.5900
            17  N1c N     6.6500  -15.1900
            18  C1b C     7.8400  -14.4900
            19  C1a C     8.9600  -15.1900
            20  C1a C     7.8400  -17.2900
            21  C1b C     5.4600  -14.4900
            22  C1a C     4.2700  -15.1900
            23  C8x C    14.2100  -19.3200
            24  C8x C    14.2100  -20.7200
            25  C8x C    15.4700  -21.4200
            26  C8x C    16.6600  -20.7200
            27  C8y C    16.6600  -19.3200
            28  C8y C    15.4700  -18.6200
            29  C5a C    17.8500  -18.6200
            30  C8y C    19.1100  -19.3200
            31  C8x C    19.1100  -20.7200
            32  C8x C    20.3000  -21.4200
            33  C8y C    21.4900  -20.7200
            34  C8x C    21.4900  -19.3200
            35  C8x C    20.3000  -18.6200
            36  C6a C    15.4700  -17.2200
            37  O6a O    16.6600  -16.5200
            38  O6a O    14.2100  -16.5200
            39  O5a O    17.8500  -17.2200
            40  O1a O    22.7053  -21.4151
BOND        43
            1     1   2 2
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    1  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16    2  14 1
            17    6  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   16  20 1
            23   17  21 1
            24   21  22 1
            25   29  39 2
            26   29  30 1
            27   23  24 2
            28   24  25 1
            29   25  26 2
            30   26  27 1
            31   27  28 2
            32   30  31 2
            33   31  32 1
            34   32  33 2
            35   33  34 1
            36   34  35 2
            37   35  30 1
            38   28  23 1
            39   28  36 1
            40   36  37 1
            41   27  29 1
            42   36  38 2
            43   33  40 1

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