KEGG   DRUG: D03360Help
Entry
D03360                      Drug                                   

Name
Diphenhydramine laurylsulfate (JAN);
Vena (TN)
Formula
C12H26O4S. C17H21NO
Exact mass
521.3175
Mol weight
521.7522
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Transporter inhibition: SLC22A2 [HSA:6582]
Drug interaction
Structure map
Antipsychotics
Hypnotics
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA32 Diphenhydramine
      D03360  Diphenhydramine laurylsulfate (JAN)
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AA Aminoalkyl ethers
     R06AA02 Diphenhydramine
      D03360  Diphenhydramine laurylsulfate (JAN)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Diphenhydramine
    D03360  Diphenhydramine laurylsulfate (JAN)
 Antiparkinson Agents
  Anticholinergics
   Diphenhydramine
    D03360  Diphenhydramine laurylsulfate (JAN)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Diphenhydramine
    D03360  Diphenhydramine laurylsulfate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2642  Antihistamines for external use
     D03360  Diphenhydramine laurylsulfate (JAN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D03360  Diphenhydramine laurylsulfate (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Third-class OTC drugs
  Inorganic and organic chemicals
   Diphenhydramine
    D03360  Diphenhydramine laurylsulfate (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Diphenhydramine
      D03360  Diphenhydramine laurylsulfate (JAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Diphenhydramine
    D03360  Diphenhydramine laurylsulfate (JAN)
 Inhbitors
  CYP2D6
   Diphenhydramine
    D03360  Diphenhydramine laurylsulfate (JAN)
BRITE hierarchy
Other DBs
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        36
            1   C1c C    20.7534  -18.7629
            2   C8y C    19.5421  -19.4675
            3   C8y C    21.9707  -19.4675
            4   O2a O    20.7593  -17.3651
            5   C8x C    19.5421  -20.8712
            6   C8x C    18.3306  -18.7629
            7   C8x C    21.9650  -20.8712
            8   C8x C    23.1762  -18.7629
            9   C1b C    21.9707  -16.6604
            10  C8x C    18.3306  -21.5641
            11  C8x C    17.1133  -19.4675
            12  C8x C    23.1762  -21.5641
            13  C8x C    24.3935  -19.4675
            14  C8x C    17.1133  -20.8712
            15  C8x C    24.3876  -20.8712
            16  C1b C    23.2072  -17.3717
            17  N1c N    24.4042  -16.6780
            18  C1a C    25.5940  -17.3624
            19  C1a C    24.4020  -15.2685
            20  C1b C    43.4700  -19.3900
            21  C1b C    42.2800  -20.0900
            22  C1b C    41.0900  -19.3900
            23  C1b C    39.8300  -20.0900
            24  C1b C    38.6400  -19.3900
            25  C1b C    37.4500  -20.0900
            26  C1b C    36.2600  -19.3900
            27  C1b C    35.0700  -20.0900
            28  C1b C    33.8100  -19.3900
            29  C1b C    32.6200  -20.0900
            30  C1b C    31.4300  -19.3900
            31  O2a O    30.2400  -20.0900
            32  C1a C    44.7300  -20.0900
            33  S4a S    28.8400  -20.0900
            34  O1d O    27.4400  -20.0900
            35  O1d O    28.8400  -18.6900
            36  O1d O    28.8400  -21.4900
BOND        36
            1     5  10 2
            2     6  11 1
            3     7  12 1
            4     8  13 2
            5    10  14 1
            6    12  15 2
            7    11  14 2
            8    13  15 1
            9     1   2 1
            10    1   3 1
            11    1   4 1
            12    2   5 1
            13    2   6 2
            14    3   7 2
            15    3   8 1
            16    4   9 1
            17    9  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   26  27 1
            28   27  28 1
            29   28  29 1
            30   29  30 1
            31   30  31 1
            32   20  32 1
            33   31  33 1
            34   33  34 1
            35   33  35 2
            36   33  36 2

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