KEGG   DRUG: D03363Help
Entry
D03363                      Drug                                   

Name
Canrenone (USAN)
Formula
C22H28O3
Exact mass
340.2038
Mol weight
340.4559
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Aldosterone antagonist
Remark
ATC code: 
Target
mineralocorticoid receptor antagonist [HSA:4306] [KO:K08555]
  Pathway
hsa04960  Aldosterone-regulated sodium reabsorption  
 
Interaction
Drug interaction
Structure map
Glucocorticoid and meneralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03D POTASSIUM-SPARING AGENTS
    C03DA Aldosterone antagonists
     C03DA03 Canrenone
      D03363  Canrenone (USAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    mineralocorticoid receptor
     Canrenone
      D03363  Canrenone (USAN)
BRITE hierarchy
Other DBs
CAS: 
976-71-6
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C1z C    26.1100  -21.4200
            2   C1z C    24.8500  -22.1200
            3   C1x C    27.2300  -22.1200
            4   O7x O    27.2300  -20.6500
            5   C1x C    24.9900  -20.6500
            6   C1y C    24.8500  -23.4500
            7   C1x C    23.7300  -21.4200
            8   C1a C    24.2200  -20.5800
            9   C1x C    27.2300  -23.4500
            10  C7x C    26.8100  -19.3200
            11  C1x C    25.4100  -19.3200
            12  C1y C    23.7300  -24.1500
            13  C1x C    22.5400  -22.1200
            14  O6a O    27.5800  -18.2700
            15  C1y C    22.5400  -23.4500
            16  C2x C    23.7300  -25.5500
            17  C1z C    21.3500  -24.1500
            18  C2x C    22.5400  -26.1800
            19  C2y C    21.3500  -25.4800
            20  C1x C    20.1600  -23.4500
            21  C1a C    21.3500  -22.7500
            22  C2x C    20.1600  -26.1800
            23  C1x C    18.9700  -24.1500
            24  C5x C    18.9700  -25.4800
            25  O5x O    17.7800  -26.1800
BOND        29
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Up
            4     1   5 1 #Down
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13   10  14 2
            14   12  15 1
            15   12  16 1
            16   15  17 1
            17   16  18 2
            18   17  19 1
            19   17  20 1
            20   17  21 1 #Up
            21   19  22 2
            22   20  23 1
            23   22  24 1
            24   24  25 2
            25    6   9 1
            26   10  11 1
            27   13  15 1
            28   18  19 1
            29   23  24 1

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