KEGG   DRUG: Cephalexin hydrochlorideHelp
Entry
D03438                      Drug                                   

Name
Cephalexin hydrochloride (USP);
Keftab (TN)
Formula
C16H17N3O4S. HCl. H2O
Exact mass
401.0812
Mol weight
401.8651
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01714  Cephalosporin skeleton group
   DG01488  Cephem
 DG01774  First-generation cephalosporin
Remark
ATC code: 
Chemical group: 
Activity
Antibacterial, Cell wall biosynthesis inhibitor
Comment
Semisynthetic cephalosporin: narrow spectrum cephalosporin
Target
penicillin binding protein
  Pathway
Peptidoglycan biosynthesis
Metabolism
Transporter: SLC15A1 [HSA:6564], SCL15A2 [HSA:6565]
Structure map
Cephalosporins - oral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DB First-generation cephalosporins
     J01DB01 Cefalexin
      D03438  Cephalexin hydrochloride (USP)
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Cephalosporins
   Cephalexin
    D03438  Cephalexin hydrochloride (USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor
   Penicillin binding proteins inhibitor
    Cephem
     First-generation cephalosporin
      Cefalexin
       D03438  Cephalexin hydrochloride (USP)
Cytochrome P450 interactions [BR:br08309]
 Transporter substrates
  SLC15A1
   Cefalexin
    D03438  Cephalexin hydrochloride (USP)
  SCL15A2
   Cefalexin
    D03438  Cephalexin hydrochloride (USP)
  MATE1
   Cefalexin
    D03438  Cephalexin hydrochloride (USP)
  MATE2
   Cefalexin
    D03438  Cephalexin hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
105879-42-3
PubChem: 
LigandBox: 
KCF data Show

ATOM        26
            1   C1y C    28.7441  -14.8853
            2   N1y N    28.7441  -16.2838
            3   C2y C    29.9553  -16.9829
            4   C2y C    31.1665  -16.2838
            5   C1x C    31.1665  -14.8853
            6   S2x S    29.9553  -14.1860
            7   C1y C    27.3456  -14.8853
            8   C5x C    27.3456  -16.2838
            9   N1b N    26.1345  -14.1860
            10  C5a C    24.9231  -14.8853
            11  O5a O    24.9231  -16.2838
            12  O5x O    26.1345  -16.9829
            13  C1c C    23.7120  -14.1860
            14  C1a C    32.3963  -16.9941
            15  C6a C    29.9553  -18.3813
            16  O6a O    28.7273  -19.0904
            17  O6a O    31.1495  -19.0709
            18  C8y C    22.4814  -14.8969
            19  C8x C    21.2718  -14.1985
            20  C8x C    20.0621  -14.8969
            21  C8x C    20.0621  -16.2937
            22  C8x C    21.2718  -16.9921
            23  C8x C    22.4814  -16.2937
            24  N1a N    23.7120  -12.7829
            25  O0  O    34.1455  -15.0437
            26  X   Cl   33.7400  -13.3700
BOND        26
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16    3  15 1
            17   15  16 2
            18   15  17 1
            19   13  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1
            26   13  24 1 #Up

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