KEGG   DRUG: D03441Help
Entry
D03441                      Drug                                   

Name
Certolizumab pegol (genetical recombination) (JAN);
Certolizumab pegol (USAN/INN);
Cimzia (TN)
Product
Formula
C2115H3252N556O673S16
Exact mass
47719.2868
Mol weight
47748.8128
Activity
Treatment of rheumatoid arthritis and inflammatory bowel disease, specifically Crohn's disease [DS:H00286]
Remark
Therapeutic category: 
ATC code: 
Comment
Indication: Crohn's disease
humanized Fab, pegylated
Target
TNF-alpha [HSA:7124] [KO:K03156]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04210  Apoptosis
hsa04350  TGF-beta signaling pathway
hsa04612  Antigen processing and presentation
hsa04620  Toll-like receptor signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04920  Adipocytokine signaling pathway
hsa05323  Rheumatoid arthritis  
 
Interaction
Drug interaction
Structure map
Antirheumatics - DMARDs and biological agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AB Tumor necrosis factor alpha (TNF-alpha) inhibitors
     L04AB05 Certolizumab pegol
      D03441  Certolizumab pegol (genetical recombination) (JAN); Certolizumab pegol (USAN/INN)
USP drug classification [BR:br08302]
 Immunological Agents
  Immune Suppressants
   Certolizumab pegol
    D03441  Certolizumab pegol (genetical recombination) (JAN); Certolizumab pegol (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D03441  Certolizumab pegol (genetical recombination) (JAN); Certolizumab pegol (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines
  TNF family
   TNF-alpha
    Certolizumab pegol
     D03441  Certolizumab pegol (genetical recombination) (JAN); Certolizumab pegol (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
428863-50-7
PubChem: 

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