KEGG   DRUG: Chloramphenicol pantothenate complexHelp
Entry
D03461                      Drug                                   

Name
Chloramphenicol pantothenate complex (USAN/INN);
Pantofenicol (TN)
Formula
(C11H12Cl2N2O5)4. (C9H16NO5)2. Ca
Exact mass
1764.2176
Mol weight
1769.0496
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01576  Amphenicol type antibacterial
Cyp substrate
 DG01639  CYP2C19 substrate
Cyp inhibitor
 DG01522  CYP3A4 inhibitor
 DG01915  CYP3A5 ihibitor
Remark
Activity
Antibacterial, Antirickettsial, Protein biosynthesis inhibitor
Comment
Amphenicol derivative
Target
50S ribosomal subunit
  Pathway
Ribosome
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX02 Chloramphenicol
      D03461  Chloramphenicol pantothenate complex (USAN/INN)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF03 Chloramphenicol
      D03461  Chloramphenicol pantothenate complex (USAN/INN)
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA05 Chloramphenicol
      D03461  Chloramphenicol pantothenate complex (USAN/INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01B AMPHENICOLS
    J01BA Amphenicols
     J01BA01 Chloramphenicol
      D03461  Chloramphenicol pantothenate complex (USAN/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA01 Chloramphenicol
      D03461  Chloramphenicol pantothenate complex (USAN/INN)
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA01 Chloramphenicol
      D03461  Chloramphenicol pantothenate complex (USAN/INN)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA08 Chloramphenicol
      D03461  Chloramphenicol pantothenate complex (USAN/INN)
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Chloramphenicol
    D03461  Chloramphenicol pantothenate complex (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
31342-36-6
PubChem: 
LigandBox: 
KCF data Show

ATOM        111
            1   C8y C    11.4112  -12.4657
            2   C1c C    11.4112  -13.8650
            3   C8x C    10.2043  -11.7533
            4   C8x C    12.6371  -11.7533
            5   C1c C    12.6180  -14.5647
            6   O1a O    10.1980  -14.5584
            7   C8x C    10.2043  -10.3410
            8   C8x C    12.6371  -10.3410
            9   N1b N    13.8248  -13.8715
            10  C1b C    12.6115  -15.9640
            11  C8y C    11.4112   -9.6477
            12  C5a C    15.0314  -14.5712
            13  O1a O    11.3983  -16.6572
            14  N2b N    11.4112   -8.2484 #+
            15  C1c C    16.2447  -13.8778
            16  O5a O    15.0314  -15.9705
            17  O3a O    10.2043   -7.5487
            18  O3a O    12.6115   -7.5359 #-
            19  X   Cl   17.4514  -14.5776
            20  X   Cl   16.2511  -12.4785
            21  C1c C    24.4573   -9.2553
            22  C1d C    23.2402   -9.9540
            23  C5a C    25.6685   -9.9540
            24  O1a O    24.4573   -7.8577
            25  C1b C    22.0291   -9.2553
            26  C1a C    22.0291  -10.6586
            27  C1a C    24.4573  -10.6586
            28  N1b N    26.8738   -9.2553
            29  O5a O    25.6685  -11.3516
            30  O1a O    20.8120   -9.9540
            31  C1b C    28.0909   -9.9540
            32  C1b C    29.3022   -9.2553
            33  C6a C    30.5133   -9.9540
            34  O6a O    31.7303   -9.2553 #-
            35  O6a O    30.5133  -11.3516
            36  Z   Ca   26.2013  -15.1450 #2+
            37  C8y C    11.4112  -12.4657
            38  C1c C    11.4112  -13.8650
            39  C1c C    12.6180  -14.5647
            40  N1b N    13.8248  -13.8715
            41  C5a C    15.0314  -14.5712
            42  C1c C    16.2447  -13.8778
            43  X   Cl   17.4514  -14.5776
            44  X   Cl   16.2511  -12.4785
            45  O5a O    15.0314  -15.9705
            46  C1b C    12.6115  -15.9640
            47  O1a O    11.3983  -16.6572
            48  O1a O    10.1980  -14.5584
            49  C8x C    10.2043  -11.7533
            50  C8x C    10.2043  -10.3410
            51  C8y C    11.4112   -9.6477
            52  N2b N    11.4112   -8.2484 #+
            53  O3a O    10.2043   -7.5487
            54  O3a O    12.6115   -7.5359 #-
            55  C8x C    12.6371  -10.3410
            56  C8x C    12.6371  -11.7533
            57  C8y C    11.4112  -12.4657
            58  C1c C    11.4112  -13.8650
            59  C1c C    12.6180  -14.5647
            60  N1b N    13.8248  -13.8715
            61  C5a C    15.0314  -14.5712
            62  C1c C    16.2447  -13.8778
            63  X   Cl   17.4514  -14.5776
            64  X   Cl   16.2511  -12.4785
            65  O5a O    15.0314  -15.9705
            66  C1b C    12.6115  -15.9640
            67  O1a O    11.3983  -16.6572
            68  O1a O    10.1980  -14.5584
            69  C8x C    10.2043  -11.7533
            70  C8x C    10.2043  -10.3410
            71  C8y C    11.4112   -9.6477
            72  N2b N    11.4112   -8.2484 #+
            73  O3a O    10.2043   -7.5487
            74  O3a O    12.6115   -7.5359 #-
            75  C8x C    12.6371  -10.3410
            76  C8x C    12.6371  -11.7533
            77  C8y C    11.4112  -12.4657
            78  C1c C    11.4112  -13.8650
            79  C1c C    12.6180  -14.5647
            80  N1b N    13.8248  -13.8715
            81  C5a C    15.0314  -14.5712
            82  C1c C    16.2447  -13.8778
            83  X   Cl   17.4514  -14.5776
            84  X   Cl   16.2511  -12.4785
            85  O5a O    15.0314  -15.9705
            86  C1b C    12.6115  -15.9640
            87  O1a O    11.3983  -16.6572
            88  O1a O    10.1980  -14.5584
            89  C8x C    10.2043  -11.7533
            90  C8x C    10.2043  -10.3410
            91  C8y C    11.4112   -9.6477
            92  N2b N    11.4112   -8.2484 #+
            93  O3a O    10.2043   -7.5487
            94  O3a O    12.6115   -7.5359 #-
            95  C8x C    12.6371  -10.3410
            96  C8x C    12.6371  -11.7533
            97  C1c C    24.4573   -9.2553
            98  C1d C    23.2402   -9.9540
            99  C1b C    22.0291   -9.2553
            100 O1a O    20.8120   -9.9540
            101 C1a C    22.0291  -10.6586
            102 C1a C    24.4573  -10.6586
            103 C5a C    25.6685   -9.9540
            104 N1b N    26.8738   -9.2553
            105 C1b C    28.0909   -9.9540
            106 C1b C    29.3022   -9.2553
            107 C6a C    30.5133   -9.9540
            108 O6a O    31.7303   -9.2553 #-
            109 O6a O    30.5133  -11.3516
            110 O5a O    25.6685  -11.3516
            111 O1a O    24.4573   -7.8577
BOND        108
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     5  10 1
            10    7  11 2
            11    9  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   12  16 2
            16   14  17 2
            17   14  18 1
            18   15  19 1
            19   15  20 1
            20    8  11 1
            21   37  38 1
            22   37  49 2
            23   37  56 1
            24   38  39 1
            25   38  48 1
            26   49  50 1
            27   56  55 2
            28   39  40 1
            29   39  46 1
            30   50  51 2
            31   40  41 1
            32   46  47 1
            33   51  52 1
            34   41  42 1
            35   41  45 2
            36   52  53 2
            37   52  54 1
            38   42  43 1
            39   42  44 1
            40   55  51 1
            41   57  58 1
            42   57  69 2
            43   57  76 1
            44   58  59 1
            45   58  68 1
            46   69  70 1
            47   76  75 2
            48   59  60 1
            49   59  66 1
            50   70  71 2
            51   60  61 1
            52   66  67 1
            53   71  72 1
            54   61  62 1
            55   61  65 2
            56   72  73 2
            57   72  74 1
            58   62  63 1
            59   62  64 1
            60   75  71 1
            61   77  78 1
            62   77  89 2
            63   77  96 1
            64   78  79 1
            65   78  88 1
            66   89  90 1
            67   96  95 2
            68   79  80 1
            69   79  86 1
            70   90  91 2
            71   80  81 1
            72   86  87 1
            73   91  92 1
            74   81  82 1
            75   81  85 2
            76   92  93 2
            77   92  94 1
            78   82  83 1
            79   82  84 1
            80   95  91 1
            81   33  34 1
            82   33  35 2
            83   21  22 1
            84   21  23 1
            85   21  24 1 #Up
            86   22  25 1
            87   22  26 1
            88   22  27 1
            89   23  28 1
            90   23  29 2
            91   25  30 1
            92   28  31 1
            93   31  32 1
            94   32  33 1
            95  107 108 1
            96  107 109 2
            97   97  98 1
            98   97 103 1
            99   97 111 1 #Up
            100  98  99 1
            101  98 101 1
            102  98 102 1
            103 103 104 1
            104 103 110 2
            105  99 100 1
            106 104 105 1
            107 105 106 1
            108 106 107 1
BRACKET     1     9.0300  -17.2200    9.0300   -6.8600
            1    17.9900   -6.8600   17.9900  -17.2200
            1  4
 ORIGINAL  1    1   2   5   9  12  15  19  20  16  10  13   6   3   7  11  14
            1   17  18   8   4
 REPEAT    1   37  38  39  40  41  42  43  44  45  46  47  48  49  50  51  52
            1   53  54  55  56  57  58  59  60  61  62  63  64  65  66  67  68
            1   69  70  71  72  73  74  75  76  77  78  79  80  81  82  83  84
            1   85  86  87  88  89  90  91  92  93  94  95  96
            2    19.6000  -12.3900   19.6000   -7.2100
            2    32.5500   -7.2100   32.5500  -12.3900
            2  2
 ORIGINAL  2   21  22  25  30  26  27  23  28  31  32  33  34  35  29  24
 REPEAT    2   97  98  99 100 101 102 103 104 105 106 107 108 109 110 111

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