KEGG   DRUG: D03475Help
Entry
D03475                      Drug                                   

Name
Chlorpheniramine polistirex (USAN)
Activity
Antihistaminic
Remark
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Chlorphenamine
      D03475  Chlorpheniramine polistirex (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Chlorpheniramine
    D03475  Chlorpheniramine polistirex (USAN)
  CYP3A4
   Chlorpheniramine
    D03475  Chlorpheniramine polistirex (USAN)
  CYP3A5
   Chlorpheniramine
    D03475  Chlorpheniramine polistirex (USAN)
  CYP3A7
   Chlorpheniramine
    D03475  Chlorpheniramine polistirex (USAN)
 Inhbitors
  CYP2D6
   Chlorpheniramine
    D03475  Chlorpheniramine polistirex (USAN)
BRITE hierarchy
Other DBs
PubChem: 

» Japanese version   » Back

DBGET integrated database retrieval system