KEGG   DRUG: D03492Help
Entry
D03492                      Drug                                   

Name
Cifenline (USAN);
Cibenzoline (INN)
Formula
C18H18N2
Exact mass
262.147
Mol weight
262.3489
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic]
Remark
ATC code: 
Drug group: 
Comment
Class I antiarrhythmic agent (Ia)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BG Other antiarrhythmics, class I and III
     C01BG07 Cibenzoline
      D03492  Cifenline (USAN); Cibenzoline (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Cibenzoline
      D03492  Cifenline (USAN); Cibenzoline (INN)
    voltage-gated sodium channel (SCN2A)
     Cibenzoline
      D03492  Cifenline (USAN); Cibenzoline (INN)
    voltage-gated sodium channel (SCN3A)
     Cibenzoline
      D03492  Cifenline (USAN); Cibenzoline (INN)
    voltage-gated sodium channel (SCN4A)
     Cibenzoline
      D03492  Cifenline (USAN); Cibenzoline (INN)
    voltage-gated sodium channel (SCN5A)
     Cibenzoline
      D03492  Cifenline (USAN); Cibenzoline (INN)
    voltage-gated sodium channel (SCN8A)
     Cibenzoline
      D03492  Cifenline (USAN); Cibenzoline (INN)
    voltage-gated sodium channel (SCN9A)
     Cibenzoline
      D03492  Cifenline (USAN); Cibenzoline (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Cibenzoline
    D03492  Cifenline (USAN); Cibenzoline (INN)
  CYP3A4
   Cibenzoline
    D03492  Cifenline (USAN); Cibenzoline (INN)
BRITE hierarchy
Other DBs
CAS: 
53267-01-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C8x C    19.5019  -17.1162
            2   C8x C    19.5019  -18.5190
            3   C8x C    20.6944  -19.2204
            4   C8x C    21.9569  -18.5190
            5   C8y C    21.9569  -17.1162
            6   C8x C    20.6944  -16.4147
            7   C1z C    23.1494  -16.4119
            8   C1x C    22.4479  -15.2195
            9   C1y C    23.8508  -15.2195
            10  C2y C    25.0690  -14.5198
            11  N2x N    26.3857  -14.9249
            12  C1x C    27.1780  -13.7977
            13  C1x C    26.3508  -12.6959
            14  N1x N    25.0473  -13.1422
            15  C8x C    24.3418  -18.5190
            16  C8y C    24.3418  -17.1162
            17  C8x C    25.6044  -19.2204
            18  C8x C    26.7968  -18.5190
            19  C8x C    26.7968  -17.1162
            20  C8x C    25.6044  -16.4147
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     8   9 1
            8     9   7 1
            9     7   8 1
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  14 1
            16    5   7 1
            17   15  16 1
            18   15  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   16  20 2
            23    7  16 1

» Japanese version   » Back

DBGET integrated database retrieval system