KEGG   DRUG: D03621Help
Entry
D03621                      Drug                                   

Name
Cyclizine (INN)
Formula
C18H22N2
Exact mass
266.1783
Mol weight
266.3807
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic
Remark
Same as: 
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AE Piperazine derivatives
     R06AE03 Cyclizine
      D03621  Cyclizine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Cyclizine
      D03621  Cyclizine (INN)
BRITE hierarchy
Other DBs
CAS: 
82-92-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C8x C     3.0800  -20.4400
            2   C8x C     3.0800  -21.8400
            3   C8x C     4.2924  -22.5400
            4   C8x C     5.5049  -21.8400
            5   C8y C     5.5049  -20.4400
            6   C8x C     4.2924  -19.7400
            7   C8x C     7.9297  -21.8400
            8   C8y C     7.9297  -20.4400
            9   C1c C     6.7173  -19.7400
            10  C8x C     9.1422  -22.5400
            11  C8x C    10.3546  -21.8400
            12  C8x C    10.3546  -20.4400
            13  C8x C     9.1422  -19.7400
            14  N1y N     6.7173  -18.3400
            15  C1x C     7.9318  -17.6388
            16  C1x C     7.9318  -16.2388
            17  N1y N     6.7193  -15.5388
            18  C1x C     5.5049  -16.2400
            19  C1x C     5.5049  -17.6400
            20  C1a C     6.7193  -14.1400
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   14  19 1
            22   17  20 1

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