KEGG   DRUG: D03622Help
Entry
D03622                      Drug                                   

Name
Cyclizine hydrochloride (USP)
Formula
C18H22N2. HCl
Exact mass
302.155
Mol weight
302.8416
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-emetic
Remark
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AE Piperazine derivatives
     R06AE03 Cyclizine
      D03622  Cyclizine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Cyclizine
      D03622  Cyclizine hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
303-25-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   X   Cl   29.2600  -15.7500
            2   C8x C    20.3696  -17.3576
            3   C8x C    20.3696  -18.7575
            4   C8x C    21.5819  -19.4574
            5   C8x C    22.7943  -18.7575
            6   C8y C    22.7943  -17.3576
            7   C8x C    21.5819  -16.6577
            8   C8x C    25.2188  -18.7575
            9   C8y C    25.2188  -17.3576
            10  C1c C    24.0065  -16.6577
            11  C8x C    26.4311  -19.4574
            12  C8x C    27.6434  -18.7575
            13  C8x C    27.6434  -17.3576
            14  C8x C    26.4311  -16.6577
            15  N1y N    24.0065  -15.2579
            16  C1x C    25.2209  -14.5568
            17  C1x C    25.2209  -13.1569
            18  N1y N    24.0085  -12.4570
            19  C1x C    22.7943  -13.1581
            20  C1x C    22.7943  -14.5580
            21  C1a C    24.0085  -11.0584
BOND        22
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     8   9 1
            8     9  10 1
            9     6  10 1
            10    8  11 2
            11   11  12 1
            12   12  13 2
            13   13  14 1
            14    9  14 2
            15   10  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   15  20 1
            22   18  21 1

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