KEGG   DRUG: D03639Help
Entry
D03639                      Drug                                   

Name
Daclizumab (USAN/INN);
Zenapax (TN)
Formula
C6394H9888N1696O2012S44
Exact mass
144031.1268
Mol weight
144119.9425
Sequence
(Heavy chain) QVQLVQSGAE VKKPGSSVKV SCKASGYTFT SYRMHWVRQA
PGQGLEWIGY INPSTGYTEY NQKFKDKATI TADESTNTAY MELSSLRSED TAVYYCARGG
GVFDYWGQGT LVTVSSASTK GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG
ALTSGVHTFP AVLQSSGLYS LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD
KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG
VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG
QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD
GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
(Disulfide bridge: 22-96; 143-199; 260-320; 366-424, Dimer: 225; 228)
(Light chain) DIQMTQSPST LSASVGDRVT ITCSASSSIS YMHWYQQKPG
KAPKLLIYTT SNLASGVPAR FSGSGSGTEF TLTISSLQPD DFATYYCHQR STYPLTFGQG
TKVEVKRTVA APSVFIFPPS DEQLKSGTAS VVCLLNNFYP REAKVQWKVD NALQSGNSQE
SVTEQDSKDS TYSLSSTLTL SKADYEKHKV YACEVTHQGL SSPVTKSFNR GEC
(Disulfide bridge: 23-87; 133-193; H219-L213, Dimer)
  Type
Peptide
Activity
Monoclonal antibody [immunosuppressant] [DS:H00083]
Remark
ATC code: 
Comment
anti-CD25 monoclonal antibody
Target
CD25 [HSA:3559] [KO:K05068]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04144  Endocytosis
hsa04630  Jak-STAT signaling pathway
hsa04640  Hematopoietic cell lineage  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC01 Daclizumab
      D03639  Daclizumab (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   interleukin 2 receptor alpha (CD25)
    Daclizumab
     D03639  Daclizumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
152923-56-3
PubChem: 
DrugBank: 

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