KEGG   DRUG: D03648Help
Entry
D03648                      Drug                                   

Name
Dapiprazole hydrochloride (USAN);
Rev-Eyes (TN)
Formula
C19H27N5. HCl
Exact mass
361.2033
Mol weight
361.9121
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Adrenergic [alpha-blocking];
Antiglaucoma agent;
Neuroleptic;
Psychotropic
Remark
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor agonist [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EX Other antiglaucoma preparations
     S01EX02 Dapiprazole
      D03648  Dapiprazole hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Dapiprazole
      D03648  Dapiprazole hydrochloride (USAN)
    alpha2-adrenergic receptor
     Dapiprazole
      D03648  Dapiprazole hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
72822-13-0
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        25
            1   X   Cl   35.3769  -18.0919
            2   C1x C    20.5800  -17.1500
            3   C1x C    20.5800  -18.4800
            4   C1x C    21.7700  -19.1800
            5   C8y C    23.0300  -18.4800
            6   N4y N    23.0300  -17.1500
            7   C1x C    21.7700  -16.4500
            8   N5x N    24.3600  -18.9700
            9   N5x N    25.1300  -17.7800
            10  C8y C    24.3600  -16.6600
            11  C1b C    24.7800  -15.3300
            12  C1b C    26.1100  -15.0500
            13  N1y N    27.0900  -16.1700
            14  C1x C    26.6700  -17.5000
            15  C1x C    27.5800  -18.4800
            16  N1y N    28.9800  -18.2000
            17  C1x C    29.4000  -16.8700
            18  C1x C    28.4900  -15.8200
            19  C8y C    29.8900  -19.2500
            20  C8x C    29.1900  -20.5100
            21  C8x C    29.8200  -21.7000
            22  C8x C    31.2200  -21.7000
            23  C8x C    31.9900  -20.5100
            24  C8y C    31.2900  -19.3200
            25  C1a C    32.0600  -18.0600
BOND        27
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     2   7 1
            7     5   8 2
            8     8   9 1
            9     9  10 2
            10    6  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   13  18 1
            20   16  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   19  24 1
            27   24  25 1

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