KEGG   DRUG: Darbepoetin alfaHelp
Entry
D03651                      Drug                                   

Name
Darbepoetin alfa (USAN/INN);
Darbepoetin alfa (genetical recombination) (JAN);
Aranesp (TN)
Product
Formula
C800H1300N228O24S5
Exact mass
14646.6117
Mol weight
14656.7202
Sequence
PPRLICDSR VLERYLLEAK EAENITTGCN ETCSLNENIT VPDTKVNFYA WKRMEVGQQA
VEVWQGLALL SEAVLRGQAL LVNSSQVNET LQLHVDKAVS GLRSLTTLLR ALGAQKEAIS
PPDAASAAPL RTITADTFRK LFRVYSNFLR GKLKLYTGEA CRTGDR
  Type
Peptide
Remark
Therapeutic category: 
ATC code: 
Activity
Anti-anemic, Erythropoietin receptor agonist
  Disease
Anemia due to chronic kidney disease [DS:H01642]
Comment
Treatment of anemia
Target
EPOR [HSA:2057] [KO:K05079]
  Pathway
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B03 ANTIANEMIC PREPARATIONS
   B03X OTHER ANTIANEMIC PREPARATIONS
    B03XA Other antianemic preparations
     B03XA02 Darbepoetin alfa
      D03651  Darbepoetin alfa (USAN/INN)
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Blood Formation Modifiers
   Darbepoetin alfa
    D03651  Darbepoetin alfa (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D03651  Darbepoetin alfa (USAN/INN); Darbepoetin alfa (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   erythropoietin receptor
    Darbepoetin alfa
     D03651  Darbepoetin alfa (USAN/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03651
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03651
BRITE hierarchy
Other DBs
CAS: 
209810-58-2
PubChem: 
DrugBank: 

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