KEGG   DRUG: Darodipine
Entry
D03655                      Drug                                   
Name
Darodipine (USAN/INN)
Formula
C19H21N3O5
Exact mass
371.1481
Mol weight
371.3871
Structure
Simcomp
Class
Cardiovascular agent
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
 DG03231  Antihypertensive
  DG01928  Dihydropyridine calcium channel blocker
Efficacy
Antihypertensive, Bronchodilator, Vasodilator, Calcium channel blocker
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Brite
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01496  Calcium channel L type blocker
    D03655  Darodipine
  DG03231  Antihypertensive
   DG01928  Dihydropyridine calcium channel blocker
    D03655  Darodipine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D03655  Darodipine (USAN/INN)
Other DBs
CAS: 72803-02-2
PubChem: 17397752
LigandBox: D03655
NIKKAJI: J22.967I
KCF data

ATOM        27
            1   C1y C     9.7763   -6.4487
            2   C2y C    10.9861   -5.7370
            3   C2y C     8.5665   -5.7370
            4   C8y C     9.7763   -8.8682
            5   C2y C    10.9861   -4.3849
            6   C7a C    12.1958   -6.4487
            7   C2y C     8.5665   -4.3849
            8   C7a C     7.4279   -6.3775
            9   C8x C    10.9861   -9.5798
            10  C8y C     8.5665   -9.5798
            11  N1x N     9.7763   -3.6733
            12  C1a C    12.1958   -3.6733
            13  O7a O    13.3345   -5.7370
            14  O6a O    12.1958   -7.8008
            15  C1a C     7.4279   -3.6733
            16  O7a O     6.2182   -5.7370
            17  O6a O     7.4279   -7.8008
            18  C8x C    10.9861  -10.8608
            19  C8y C     8.5665  -10.8608
            20  C1b C    14.5442   -6.4487
            21  C1b C     5.0084   -6.3775
            22  C8x C     9.7763  -11.5724
            23  C1a C    15.7826   -5.7471
            24  N5x N     7.3483   -9.1840
            25  O2x O     6.5953  -10.2203
            26  N5x N     7.3483  -11.2566
            27  C1a C     3.8421   -5.6454
BOND        29
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    6  14 2
            14    7  15 1
            15    8  16 1
            16    8  17 2
            17    9  18 1
            18   10  19 1
            19   13  20 1
            20   16  21 1
            21   18  22 2
            22    7  11 1
            23   19  22 1
            24   20  23 1
            25   10  24 2
            26   24  25 1
            27   25  26 1
            28   19  26 2
            29   21  27 1

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Ontology (2)   
   KEGG BRITE (2)   
Drug (3)   
   KEGG DGROUP (2)   
   LigandBox (1)   
Chemical substance (2)   
   PubChem (1)   
   NIKKAJI (1)   
Gene (8)   
   KEGG ORTHOLOGY (4)   
   KEGG GENES (4)   
All databases (15)   

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