KEGG   DRUG: Deflazacort
Entry
D03671                      Drug                                   
Name
Deflazacort (USAN/INN);
Emflaza (TN)
Product
EMFLAZA (PTC Therapeutics)
  Generic
DEFLAZACORT (Aurobindo Pharma Limited)
Formula
C25H31NO6
Exact mass
441.2151
Mol weight
441.5167
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Transporter substrate
 DG01665  ABCB1 substrate
Remark
ATC code: H02AB13
Product: D03671<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Duchenne muscular dystrophy [DS:H01963]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: ABCB1 [HSA:5243]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB13 Deflazacort
      D03671  Deflazacort (USAN/INN) <US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Deflazacort
   D03671  Deflazacort (USAN/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    D03671  Deflazacort
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D03671  Deflazacort
 Transporter substrate
  DG01665  ABCB1 substrate
   D03671  Deflazacort
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D03671  Deflazacort
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D03671  Deflazacort (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03671
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03671
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03671
 Drug transporters
  D03671
Other DBs
CAS: 14484-47-0
PubChem: 17397767
LigandBox: D03671
NIKKAJI: J83.648F
KCF data

ATOM        32
            1   C2x C     8.1200  -22.3300
            2   C5x C     8.1200  -23.7300
            3   C2x C     9.3324  -24.4300
            4   C2y C    10.5449  -23.7300
            5   C1z C    10.5449  -22.3300
            6   C2x C     9.3324  -21.6300
            7   C1x C    11.7573  -24.4300
            8   C1x C    12.9697  -23.7300
            9   C1y C    12.9697  -22.3300
            10  C1y C    11.7573  -21.6300
            11  C1y C    14.1822  -21.6300
            12  C1z C    14.1822  -20.2300
            13  C1x C    12.9697  -19.5300
            14  C1y C    11.7573  -20.2300
            15  C1x C    16.6070  -21.6300
            16  C1y C    16.6070  -20.2300
            17  C1z C    15.3946  -19.5300
            18  O5x O     6.9076  -24.4300
            19  C5a C    15.3946  -17.7800
            20  O5a O    16.6111  -17.0777
            21  C1b C    14.1862  -17.0823
            22  O7a O    12.9927  -17.7716
            23  C7a C    11.8044  -17.0855
            24  C1a C    10.6137  -17.7732
            25  O6a O    11.8042  -15.6802
            26  C1a C    14.1822  -18.8300
            27  O1a O    10.5469  -19.5312
            28  C1a C    10.5449  -20.9300
            29  O2x O    18.0070  -20.2300
            30  N2x N    16.6070  -18.8300
            31  C2y C    18.0070  -18.8300
            32  C1a C    18.9884  -17.8485
BOND        36
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22   17  19 1 #Up
            23   19  20 2
            24   19  21 1
            25   21  22 1
            26   22  23 1
            27   23  24 1
            28   23  25 2
            29   12  26 1 #Up
            30   14  27 1 #Up
            31    5  28 1 #Up
            32   16  29 1 #Down
            33   17  30 1 #Down
            34   30  31 2
            35   31  29 1
            36   31  32 1

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Ontology (8)   
   KEGG BRITE (8)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (4)   
   KEGG DGROUP (3)   
   LigandBox (1)   
Chemical substance (2)   
   PubChem (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (17)   

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