| Entry |
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| Name |
Desloratadine (USAN/INN);
Clarinex (TN)
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| Product |
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| Generic |
DESLORATADINE (AvKARE), DESLORATADINE (AvPAK), DESLORATADINE (Belcher Pharmaceuticals), DESLORATADINE (Dr. Reddy's Laboratories Limited), DESLORATADINE (Lupin Pharmaceuticals), DESLORATADINE (Mylan Pharmaceuticals), DESLORATADINE (Northstar Rx LLC), DESLORATADINE (Paddock Laboratories), DESLORATADINE (Sandoz), DESLORATADINE (Sun Pharmaceutical Industries Limited), DESLORATADINE (Virtus Pharmaceuticals) |
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| Formula |
C19H19ClN2
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| Exact mass |
310.1237
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| Mol weight |
310.8206
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| Structure |
     |
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| Activity |
Treatment of seasonal allergic rhinitis [H1 receptor antagonist]
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| Remark |
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| Target |
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| Pathway |
hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction | |
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| Interaction |
Genomic biomarker: CYP2D6 [HSA: 1565]
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AX Other antihistamines for systemic use
R06AX27 Desloratadine
D03693 Desloratadine (USAN/INN)
USP drug classification [BR:br08302]
Respiratory Tract Agents
Antihistamines
Histamine1 (H1) Receptor Antagonists, Mildly / Non-sedating
Desloratadine
D03693 Desloratadine (USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
H1-receptor [HSA:3269] [KO:K04149]
Desloratadine [ATC:R06AX27]
D03693 Desloratadine (USAN/INN)
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| Other DBs |
CAS: 100643-71-8 PubChem: DrugBank: LigandBox: |
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| KCF data |
ATOM 22
1 C1x C 15.9600 -18.2700
2 C8y C 15.1200 -17.1500
3 C8y C 15.4000 -15.7500
4 C2y C 16.7300 -15.1900
5 C1x C 17.3600 -18.2700
6 C8y C 17.9200 -15.8200
7 C8y C 18.2700 -17.2200
8 C8x C 14.4200 -14.8400
9 C8x C 13.0900 -15.1900
10 C8y C 12.7400 -16.5900
11 C8x C 13.7200 -17.5000
12 C8x C 19.6000 -17.6400
13 C8x C 20.6500 -16.7300
14 C8x C 20.3700 -15.3300
15 N5x N 18.9700 -14.9100
16 C2y C 16.7300 -13.7900
17 X Cl 11.3979 -16.9886
18 C1x C 17.9424 -13.0900
19 C1x C 17.9424 -11.6900
20 N1x N 16.7300 -10.9900
21 C1x C 15.5176 -11.6900
22 C1x C 15.5176 -13.0900
BOND 25
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 4 16 2
19 10 17 1
20 16 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 16 22 1
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