| Entry |
|
|---|
| Name |
Desloratadine (USAN/INN);
Clarinex (TN)
|
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C19H19ClN2
|
|---|
| Exact mass |
310.1237
|
|---|
| Mol weight |
310.8206
|
|---|
| Structure |
     |
|---|
| Activity |
Treatment of seasonal allergic rhinitis [H1 receptor antagonist]
|
|---|
| Remark |
|
|---|
| Target |
|
|---|
| Pathway |
hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction | |
|
|---|
| Interaction |
Genomic biomarker: CYP2D6 [HSA: 1565]
 |
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AX Other antihistamines for systemic use
R06AX27 Desloratadine
D03693 Desloratadine (USAN/INN)
USP drug classification [BR:br08302]
Respiratory Tract Agents
Antihistamines
Histamine1 (H1) Receptor Antagonists, Mildly / Non-sedating
Desloratadine
D03693 Desloratadine (USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
H1-receptor [HSA:3269] [KO:K04149]
Desloratadine [ATC:R06AX27]
D03693 Desloratadine (USAN/INN)
 |
|---|
| Other DBs |
CAS: 100643-71-8 PubChem: DrugBank: LigandBox: |
|---|
| KCF data |
ATOM 22
1 C1x C 15.9600 -18.2700
2 C8y C 15.1200 -17.1500
3 C8y C 15.4000 -15.7500
4 C2y C 16.7300 -15.1900
5 C1x C 17.3600 -18.2700
6 C8y C 17.9200 -15.8200
7 C8y C 18.2700 -17.2200
8 C8x C 14.4200 -14.8400
9 C8x C 13.0900 -15.1900
10 C8y C 12.7400 -16.5900
11 C8x C 13.7200 -17.5000
12 C8x C 19.6000 -17.6400
13 C8x C 20.6500 -16.7300
14 C8x C 20.3700 -15.3300
15 N5x N 18.9700 -14.9100
16 C2y C 16.7300 -13.7900
17 X Cl 11.3979 -16.9886
18 C1x C 17.9424 -13.0900
19 C1x C 17.9424 -11.6900
20 N1x N 16.7300 -10.9900
21 C1x C 15.5176 -11.6900
22 C1x C 15.5176 -13.0900
BOND 25
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 4 16 2
19 10 17 1
20 16 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 16 22 1
|
|---|
