KEGG   DRUG: D03693Help
Entry
D03693                      Drug                                   

Name
Desloratadine (USAN/INN);
Clarinex (TN)
Product
  Generic
Formula
C19H19ClN2
Exact mass
310.1237
Mol weight
310.8206
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of seasonal allergic rhinitis [H1 receptor antagonist]
Remark
ATC code: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX27 Desloratadine
      D03693  Desloratadine (USAN/INN)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Desloratadine
    D03693  Desloratadine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Desloratadine
      D03693  Desloratadine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
100643-71-8
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        22
            1   C1x C    15.9600  -18.2700
            2   C8y C    15.1200  -17.1500
            3   C8y C    15.4000  -15.7500
            4   C2y C    16.7300  -15.1900
            5   C1x C    17.3600  -18.2700
            6   C8y C    17.9200  -15.8200
            7   C8y C    18.2700  -17.2200
            8   C8x C    14.4200  -14.8400
            9   C8x C    13.0900  -15.1900
            10  C8y C    12.7400  -16.5900
            11  C8x C    13.7200  -17.5000
            12  C8x C    19.6000  -17.6400
            13  C8x C    20.6500  -16.7300
            14  C8x C    20.3700  -15.3300
            15  N5x N    18.9700  -14.9100
            16  C2y C    16.7300  -13.7900
            17  X   Cl   11.3979  -16.9886
            18  C1x C    17.9424  -13.0900
            19  C1x C    17.9424  -11.6900
            20  N1x N    16.7300  -10.9900
            21  C1x C    15.5176  -11.6900
            22  C1x C    15.5176  -13.0900
BOND        25
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 2
            19   10  17 1
            20   16  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   16  22 1

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