KEGG   DRUG: Dexfenfluramine hydrochlorideHelp
Entry
D03713                      Drug                                   

Name
Dexfenfluramine hydrochloride (USAN);
d-Fenfluramine hydrochloride;
Redux (TN)
Formula
C12H16F3N. HCl
Exact mass
267.1002
Mol weight
267.7183
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Other
 DG01706  Antiobesity
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
Cyp substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: 
Chemical group: 
Activity
Appetite suppressant (systemic), Serotonin reuptake inhibitor
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037];
  Pathway
Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
   A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
    A08AA Centrally acting antiobesity products
     A08AA04 Dexfenfluramine
      D03713  Dexfenfluramine hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A3 (dopamine transporter)
     Dexfenfluramine
      D03713  Dexfenfluramine hydrochloride (USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Dexfenfluramine
    D03713  Dexfenfluramine hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
3239-45-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        17
            1   C1b C    17.8500  -15.4000
            2   C1c C    19.1100  -16.1000
            3   N1b N    20.3000  -15.4000
            4   C8y C    16.5900  -16.1000
            5   C8x C    15.4000  -15.4700
            6   C8y C    14.2100  -16.1700
            7   C8x C    14.2100  -17.5700
            8   C8x C    15.4000  -18.2000
            9   C8x C    16.5900  -17.5000
            10  C1d C    13.0200  -15.4000
            11  X   F    11.7600  -14.7000
            12  X   F    12.3200  -16.6600
            13  X   F    13.6500  -14.2100
            14  C1a C    19.1100  -17.5000
            15  C1b C    21.4900  -16.1000
            16  C1a C    22.7500  -15.4000
            17  X   Cl   23.8000  -18.2000
BOND        16
            1     1   2 1
            2     2   3 1
            3     1   4 1
            4     4   5 2
            5     5   6 1
            6     6   7 2
            7     7   8 1
            8     8   9 2
            9     4   9 1
            10    6  10 1
            11   10  11 1
            12   10  12 1
            13   10  13 1
            14    2  14 1 #Up
            15    3  15 1
            16   15  16 1

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