KEGG   DRUG: D03729Help
Entry
D03729                      Drug                                   

Name
Dexpropranolol hydrochloride (USAN)
Formula
C16H21NO2. HCl
Exact mass
295.1339
Mol weight
295.8044
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic];
Anti-adrenergic [beta-receptor]
Comment
Class II antiarrhythmic agent
See Propranolol [DR:D08443]
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Drug interaction
Structure map
Naphthalene family
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Dexpropranolol
      D03729  Dexpropranolol hydrochloride (USAN)
    beta2-adrenergic receptor
     Dexpropranolol
      D03729  Dexpropranolol hydrochloride (USAN)
    beta3-adrenergic receptor
     Dexpropranolol
      D03729  Dexpropranolol hydrochloride (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Dexpropranolol
    D03729  Dexpropranolol hydrochloride (USAN)
  CYP2C19
   Dexpropranolol
    D03729  Dexpropranolol hydrochloride (USAN)
  CYP2D6
   Dexpropranolol
    D03729  Dexpropranolol hydrochloride (USAN)
  CYP3A4
   Dexpropranolol
    D03729  Dexpropranolol hydrochloride (USAN)
  CYP3A5
   Dexpropranolol
    D03729  Dexpropranolol hydrochloride (USAN)
  CYP3A7
   Dexpropranolol
    D03729  Dexpropranolol hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
13071-11-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C8x C    19.9417  -19.4715
            2   C8x C    19.9417  -20.8791
            3   C8x C    21.1607  -21.5830
            4   C8y C    22.3798  -20.8791
            5   C8y C    22.3798  -19.4715
            6   C8x C    21.1607  -18.7676
            7   C8x C    23.5988  -21.5830
            8   C8x C    24.8179  -20.8791
            9   C8x C    24.8179  -19.4715
            10  C8y C    23.5988  -18.7676
            11  O2a O    23.5988  -17.3600
            12  C1b C    24.8200  -16.6550
            13  C1c C    26.0231  -17.3498
            14  C1b C    27.2163  -16.6608
            15  N1b N    28.4143  -17.3528
            16  C1c C    29.6102  -16.6623
            17  C1a C    30.8069  -17.3535
            18  C1a C    29.6104  -15.2487
            19  O1a O    26.0228  -18.7210
            20  X   Cl   30.8000  -20.8600
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   16  18 1
            20   13  19 1 #Up

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