KEGG   DRUG: DextroamphetamineHelp
Entry
D03740                      Drug                                   

Name
Dextroamphetamine (USAN);
Dexamfetamine (INN)
Formula
C9H13N
Exact mass
135.1048
Mol weight
135.2062
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01970  Agents for ADHD
Cyp substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07884
ATC code: N06BA02
Chemical structure group: DG00967
Product (DG00967): D02078<US>
Efficacy
Stimulant (central)
Comment
Compoment of Biphetamine (TN)
Target
SLC18A2 (VMAT2) [HSA:6571] [KO:K08155]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
hsa05031  Amphetamine addiction
Interaction
Drug interaction
Structure map
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA02 Dexamfetamine
      D03740  Dextroamphetamine (USAN)
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Amphetamines
   Dextroamphetamine
    D03740  Dextroamphetamine (USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D03740  Dextroamphetamine (USAN)
    SLC6A3 (DAT1)
     D03740  Dextroamphetamine (USAN)
    SLC6A4 (HTT)
     D03740  Dextroamphetamine (USAN)
Prodrugs [br08324.html]
 D03740
BRITE hierarchy
Other DBs
CAS: 51-64-9
PubChem: 17397829
ChEBI: 4469
ChEMBL: CHEMBL612
DrugBank: DB01576
PDB-CCD: 1WE[PDBj]
LigandBox: D03740
NIKKAJI: J4.121A
KCF data Show

ATOM        10
            1   C8y C    18.0880  -15.4844
            2   C8x C    16.8267  -14.7837
            3   C8x C    18.0880  -16.8859
            4   C1b C    19.2792  -14.7837
            5   C8x C    15.6355  -15.4844
            6   C8x C    16.8267  -17.5866
            7   C1c C    20.4704  -15.4844
            8   C8x C    15.6355  -16.8859
            9   N1a N    21.6616  -14.7837
            10  C1a C    20.4704  -16.8859
BOND        10
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     7   9 1
            9     7  10 1 #Up
            10    6   8 1

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