KEGG   DRUG: D03742Help
Entry
D03742                      Drug                                   

Name
Dextromethorphan (USP)
Formula
C18H25NO
Exact mass
271.1936
Mol weight
271.3972
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antitussive
Remark
Same as: 
ATC code: 
Drug group: 
Target
N-methyl-D-aspartate receptor antagonist [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R05 COUGH AND COLD PREPARATIONS
   R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
    R05DA Opium alkaloids and derivatives
     R05DA09 Dextromethorphan
      D03742  Dextromethorphan (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Dextromethorphan
    D03742  Dextromethorphan (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), NMDA
    N-methyl-D-aspartate receptor
     Dextromethorphan
      D03742  Dextromethorphan (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Dextromethorphan
    D03742  Dextromethorphan (USP)
  CYP3A4
   Dextromethorphan
    D03742  Dextromethorphan (USP)
BRITE hierarchy
Other DBs
CAS: 
125-71-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C1z C    33.2856  -19.2724
            2   C8y C    33.2913  -17.9380
            3   C1y C    34.4453  -19.9427
            4   C1x C    34.2413  -18.3226
            5   C1x C    32.1259  -19.9368
            6   C8y C    34.4570  -17.2736
            7   C8x C    32.1492  -17.2619
            8   C1y C    35.6051  -19.2841
            9   C1x C    34.4453  -21.2772
            10  C1x C    36.7415  -18.3167
            11  C1x C    32.1259  -21.2772
            12  C1x C    35.6108  -17.9496
            13  C8x C    34.4687  -15.9449
            14  C8y C    32.1609  -15.9273
            15  N1y N    36.7590  -19.9601
            16  C1x C    33.2856  -21.9534
            17  C8x C    33.3206  -15.2688
            18  O2a O    31.0069  -15.2455
            19  C1a C    38.2276  -19.9368
            20  C1a C    29.8412  -15.9040
BOND        23
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1 #Down
            15    9  16 1
            16   13  17 2
            17   14  18 1
            18   15  19 1
            19   18  20 1
            20    8  12 1
            21   10  15 1
            22   11  16 1
            23   14  17 1

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