KEGG   DRUG: Dextromethorphan polistirexHelp
Entry
D03744                      Drug                                   

Name
Dextromethorphan polistirex (USAN);
Delsym (TN)
Class
Neuropsychiatric agent
 DG01498  NMDA receptor antagonist
Cyp substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: 
Chemical group: 
Activity
Antitussive
Comment
Opium alkaloid, morphinan, nonnarcotic
Target
SIGMAR1 [HSA:10280] [KO:K20719];
GRIN (NMDAR) [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Long-term potentiation
Glutamatergic synapse
Interaction
Drug interaction
Structure map
N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R05 COUGH AND COLD PREPARATIONS
   R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
    R05DA Opium alkaloids and derivatives
     R05DA09 Dextromethorphan
      D03744  Dextromethorphan polistirex (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), NMDA
    N-methyl-D-aspartate receptor
     Dextromethorphan
      D03744  Dextromethorphan polistirex (USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Dextromethorphan
    D03744  Dextromethorphan polistirex (USAN)
  CYP3A4
   Dextromethorphan
    D03744  Dextromethorphan polistirex (USAN)
BRITE hierarchy
Other DBs
PubChem: 
DrugBank: 

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