KEGG   DRUG: Dextromethorphan polistirexHelp
Entry
D03744                      Drug                                   

Name
Dextromethorphan polistirex (USAN);
Delsym (TN)
Class
Neuropsychiatric agent
 DG01498  NMDA receptor antagonist
Cyp substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: R05DA09
Chemical structure group: DG01078
Product (DG01078): D00848<JP>
Efficacy
Antitussive
Comment
Opium alkaloid, morphinan, nonnarcotic
Target
SIGMAR1 [HSA:10280] [KO:K20719]
GRIN (NMDAR) [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07235  N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R05 COUGH AND COLD PREPARATIONS
   R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
    R05DA Opium alkaloids and derivatives
     R05DA09 Dextromethorphan
      D03744  Dextromethorphan polistirex (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), NMDA
    GRIN (NMDAR)
     D03744  Dextromethorphan polistirex (USAN)
 Transporters
  Other transporters
   Sigma non-opioid intracellular receptor
    SIGMAR1
     D03744  Dextromethorphan polistirex (USAN)
BRITE hierarchy
Other DBs
PubChem: 17397833
DrugBank: DB00514

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