KEGG   DRUG: D03822Help
Entry
D03822                      Drug                                   

Name
Rivastigmine (JAN/USAN/INN);
Exelon (TN)
Product
Formula
C14H22N2O2
Exact mass
250.1681
Mol weight
250.3367
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of Alzheimer's disease [acetylcholinesterase inhibitor] [DS:H00056]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
acetylcholinesterase (AChE) inhibitor [HSA:43] [KO:K01049];
butyrylcholinesterase (BChE) inhibitor [HSA:590] [KO:K01050]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse  
 
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D03822  Rivastigmine (JAN/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA03 Rivastigmine
      D03822  Rivastigmine (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Rivastigmine
    D03822  Rivastigmine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE) [HSA:43] [KO:K01049]
    Rivastigmine [ATC:N06DA03]
     D03822  Rivastigmine (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
123441-03-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C8y C    33.4600  -18.9700
            2   C8x C    34.6500  -18.2700
            3   C8x C    33.4600  -20.3700
            4   O7a O    32.2000  -18.2700
            5   C8y C    35.8400  -18.9700
            6   C8x C    34.6500  -21.0700
            7   C7a C    31.0100  -18.9700
            8   C8x C    35.8400  -20.3700
            9   N1c N    29.8200  -18.2700
            10  O6a O    31.0100  -20.3700
            11  C1a C    28.5600  -18.9700
            12  C1c C    37.1000  -18.2700
            13  N1c N    38.2900  -18.9700
            14  C1a C    37.1000  -16.8700
            15  C1a C    38.2900  -20.3700
            16  C1a C    39.4800  -18.2700
            17  C1b C    29.8200  -16.8700
            18  C1a C    31.0800  -16.1700
BOND        18
            1     5   8 2
            2     7   9 1
            3     7  10 2
            4     9  11 1
            5     6   8 1
            6     5  12 1
            7     1   2 2
            8    12  13 1
            9     1   3 1
            10   12  14 1 #Down
            11    1   4 1
            12   13  15 1
            13    2   5 1
            14   13  16 1
            15    3   6 2
            16    9  17 1
            17    4   7 1
            18   17  18 1

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