KEGG   DRUG: RivastigmineHelp
Entry
D03822                      Drug                                   

Name
Rivastigmine (JAN/USAN/INN);
Exelon (TN)
Product
  Generic
Formula
C14H22N2O2
Exact mass
250.1681
Mol weight
250.3367
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
  DG01594  Butyrylcholinesterase inhibitor
Unclassified
 DG01968  Agents for Alzheimer-type dementia
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Nootropic, Acetylcholinesterase inhibitor
  Disease
Alzheimer's disease [DS:H00056]
Comment
Physostigmine derivative
Target
ACHE [HSA:43] [KO:K01049];
BCHE [HSA:590] [KO:K01050]
  Pathway
Glycerophospholipid metabolism
Cholinergic synapse
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA03 Rivastigmine
      D03822  Rivastigmine (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Rivastigmine
    D03822  Rivastigmine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D03822  Rivastigmine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Rivastigmine
     D03822  Rivastigmine (JAN/USAN/INN)
   butyrylcholinesterase (BChE)
    Rivastigmine
     D03822  Rivastigmine (JAN/USAN/INN)
Neurological agents [br08367.html]
 Anti-Alzheimer agents
  D03822
BRITE hierarchy
Other DBs
CAS: 
123441-03-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C8y C    33.4600  -18.9700
            2   C8x C    34.6500  -18.2700
            3   C8x C    33.4600  -20.3700
            4   O7a O    32.2000  -18.2700
            5   C8y C    35.8400  -18.9700
            6   C8x C    34.6500  -21.0700
            7   C7a C    31.0100  -18.9700
            8   C8x C    35.8400  -20.3700
            9   N1c N    29.8200  -18.2700
            10  O6a O    31.0100  -20.3700
            11  C1a C    28.5600  -18.9700
            12  C1c C    37.1000  -18.2700
            13  N1c N    38.2900  -18.9700
            14  C1a C    37.1000  -16.8700
            15  C1a C    38.2900  -20.3700
            16  C1a C    39.4800  -18.2700
            17  C1b C    29.8200  -16.8700
            18  C1a C    31.0800  -16.1700
BOND        18
            1     5   8 2
            2     7   9 1
            3     7  10 2
            4     9  11 1
            5     6   8 1
            6     5  12 1
            7     1   2 2
            8    12  13 1
            9     1   3 1
            10   12  14 1 #Down
            11    1   4 1
            12   13  15 1
            13    2   5 1
            14   13  16 1
            15    3   6 2
            16    9  17 1
            17    4   7 1
            18   17  18 1

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