KEGG   DRUG: D03833Help
Entry
D03833                      Drug                                   

Name
Indinavir (USAN);
Indinavir hydrate
Formula
C36H47N5O4. H2O
Exact mass
631.3734
Mol weight
631.8048
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiviral [DS:H00406]
Remark
ATC code: 
Drug group: 
Target
HIV protease inhibitor [CPD:C19849]
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Drug interaction
Structure map
Anti-HIV agents
HIV protease inhibitors
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AE Protease inhibitors
     J05AE02 Indinavir
      D03833  Indinavir (USAN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Protease Inhibitors
   Indinavir
    D03833  Indinavir (USAN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HIV agents
   Protease inhibitor (PIs)
    Peptidic
     Indinavir
      D03833  Indinavir (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Indinavir
    D03833  Indinavir (USAN)
  CYP3A5
   Indinavir
    D03833  Indinavir (USAN)
  CYP3A7
   Indinavir
    D03833  Indinavir (USAN)
 Inhbitors
  CYP3A
   Indinavir
    D03833  Indinavir (USAN)
BRITE hierarchy
Other DBs
CAS: 
180683-37-8
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        46
            1   C8y C    15.6800  -19.3200
            2   C1y C    16.7300  -18.4100
            3   C8y C    14.4200  -18.6200
            4   C8x C    15.6800  -20.7200
            5   C1y C    16.1700  -17.0800
            6   N1b N    17.9200  -19.1100
            7   C1x C    14.7700  -17.2200
            8   C8x C    13.2300  -19.3200
            9   C8x C    14.4200  -21.4200
            10  O1a O    16.8700  -15.8900
            11  C5a C    19.2500  -18.3400
            12  C8x C    13.2300  -20.7200
            13  C1c C    20.4400  -19.0400
            14  O5a O    19.2500  -16.9400
            15  C1b C    20.4400  -20.4400
            16  C1b C    21.6300  -18.3400
            17  C8y C    19.2500  -21.1400
            18  C1c C    22.9600  -19.0400
            19  C8x C    19.2500  -22.5400
            20  C8x C    18.0600  -20.4400
            21  C1b C    24.1500  -18.3400
            22  O1a O    22.9600  -20.4400
            23  C8x C    17.9900  -23.2400
            24  C8x C    16.8000  -21.1400
            25  N1y N    25.3400  -19.0400
            26  C8x C    16.8000  -22.5400
            27  C1y C    26.6000  -18.3400
            28  C1x C    25.3400  -20.4400
            29  C1x C    27.7900  -19.0400
            30  C5a C    26.6000  -16.9400
            31  C1x C    26.6000  -21.1400
            32  N1y N    27.7900  -20.4400
            33  N1b N    27.7900  -16.2400
            34  O5a O    25.3400  -16.2400
            35  C1b C    28.9800  -21.1400
            36  C1d C    28.9800  -16.9400
            37  C8y C    30.2400  -20.4400
            38  C1a C    30.3100  -17.7100
            39  C1a C    28.4200  -17.8500
            40  C1a C    29.6800  -15.8200
            41  C8x C    30.2400  -19.0400
            42  C8x C    31.4300  -21.1400
            43  C8x C    31.4300  -18.3400
            44  N5x N    32.6200  -20.4400
            45  C8x C    32.6200  -19.0400
            46  O0  O    37.1000  -19.1100
BOND        49
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Up
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1 #Up
            10    6  11 1
            11    8  12 2
            12   11  13 1
            13   11  14 2
            14   13  15 1 #Up
            15   13  16 1
            16   15  17 1
            17   16  18 1
            18   17  19 2
            19   17  20 1
            20   18  21 1
            21   18  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   23  26 2
            26   25  27 1
            27   25  28 1
            28   27  29 1
            29   27  30 1 #Down
            30   28  31 1
            31   29  32 1
            32   30  33 1
            33   30  34 2
            34   32  35 1
            35   33  36 1
            36   35  37 1
            37   36  38 1
            38   36  39 1
            39   36  40 1
            40   37  41 1
            41   37  42 2
            42   41  43 2
            43   42  44 1
            44   43  45 1
            45    5   7 1
            46    9  12 1
            47   24  26 1
            48   31  32 1
            49   44  45 2

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