| Entry |
|
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| Name |
Fosamprenavir calcium (USAN);
Lexiva (TN)
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| Product |
|
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| Formula |
C25H34N3O9PS. Ca
|
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| Exact mass |
623.1379
|
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| Mol weight |
623.6689
|
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| Structure |
     |
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| Activity |
Antiviral [HIV protease inhibitor] [DS: H00406]
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| Remark |
|
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| Target |
HIV protease inhibitor [CPD: C19849] |
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565], CYP1A2 [HSA: 1544], CYP2C9 [HSA: 1559]
|
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| Interaction |
CYP inhibition: CYP3A inhibitor [KO: K07424]
 |
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| Structure map |
| Anti-HIV agents | | HIV protease inhibitors |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AE Protease inhibitors
J05AE07 Fosamprenavir
D03835 Fosamprenavir calcium (USAN)
USP drug classification [BR:br08302]
Antivirals
Anti-HIV Agents, Protease Inhibitors
Fosamprenavir
D03835 Fosamprenavir calcium (USAN)
Antiinfectives [BR:br08307]
Antivirals
Anti-HIV agent
Protease inhibitor (PIs)
Nonpeptidic
Fosamprenavir [ATC:J05AE07]
D03835 Fosamprenavir calcium (USAN)
 |
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| Other DBs |
CAS: 226700-81-8 PubChem: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 40
1 N1c N 29.3300 -16.0300
2 C1b C 30.5200 -15.3300
3 S4a S 27.7900 -15.3300
4 C1c C 31.7800 -16.0300
5 C8y C 26.3200 -16.0300
6 C1c C 32.9700 -15.3300
7 C1b C 32.9700 -13.9300
8 N1b N 34.1600 -16.0300
9 C8y C 31.7800 -13.2300
10 C7a C 35.3500 -15.3300
11 C8x C 30.5200 -13.9300
12 C8x C 31.7800 -11.8300
13 O7a O 36.6100 -16.0300
14 O6a O 35.3500 -13.9300
15 C8x C 29.3300 -13.2300
16 C8x C 30.5200 -11.1300
17 C1y C 37.8000 -15.4000
18 C8x C 29.3300 -11.8300
19 C8x C 26.3200 -17.4300
20 C8x C 25.1300 -18.1300
21 C8y C 23.9400 -17.4300
22 C8x C 23.9400 -16.0300
23 C8x C 25.1300 -15.3300
24 N1a N 22.6800 -18.2000
25 C1b C 29.3300 -18.0600
26 O2b O 31.7100 -18.1300
27 P1b P 32.9700 -18.9000
28 O1c O 34.0900 -19.5300 #-
29 O3c O 28.7700 -14.3500
30 O3c O 26.8100 -14.3500
31 O1c O 32.2700 -20.0900 #-
32 O1c O 33.6700 -17.7100
33 C1c C 28.1400 -18.7600
34 C1a C 28.1400 -20.1600
35 C1a C 26.9500 -18.0600
36 C1x C 37.8000 -14.0000
37 C1x C 39.1300 -15.8200
38 C1x C 39.9700 -14.7000
39 O2x O 39.1300 -13.5800
40 Z Ca 36.0500 -19.6000 #2+
BOND 41
1 1 2 1
2 1 3 1
3 2 4 1
4 3 5 1
5 4 6 1
6 6 7 1 #Down
7 6 8 1
8 7 9 1
9 8 10 1
10 9 11 2
11 9 12 1
12 10 13 1
13 10 14 2
14 11 15 1
15 12 16 2
16 17 13 1 #Down
17 15 18 2
18 16 18 1
19 5 19 2
20 19 20 1
21 20 21 2
22 21 22 1
23 22 23 2
24 5 23 1
25 21 24 1
26 1 25 1
27 4 26 1 #Down
28 26 27 1
29 27 28 1
30 3 29 2
31 3 30 2
32 27 31 1
33 27 32 2
34 25 33 1
35 33 34 1
36 33 35 1
37 17 36 1
38 17 37 1
39 37 38 1
40 38 39 1
41 36 39 1
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