KEGG   DRUG: D03991Help
Entry
D03991                      Drug                                   

Name
Encainide hydrochloride (USAN)
Formula
C22H28N2O2. HCl
Exact mass
388.1918
Mol weight
388.9309
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic]
Remark
ATC code: 
Drug group: 
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC08 Encainide
      D03991  Encainide hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
    voltage-gated sodium channel (SCN2A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
    voltage-gated sodium channel (SCN3A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
    voltage-gated sodium channel (SCN4A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
    voltage-gated sodium channel (SCN5A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
    voltage-gated sodium channel (SCN8A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
    voltage-gated sodium channel (SCN9A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Encainide
    D03991  Encainide hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
66794-74-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   X   Cl   41.7199  -19.3899
            2   C8y C    32.6900  -19.6700
            3   C8y C    33.8800  -18.9700
            4   N1b N    31.5000  -18.9700
            5   C8x C    32.6900  -21.0700
            6   C1b C    33.8800  -17.5700
            7   C8x C    35.1400  -19.6700
            8   C5a C    30.2400  -19.6700
            9   C8x C    33.8800  -21.7700
            10  C1b C    35.1400  -16.8700
            11  C8x C    35.1400  -21.0700
            12  C8y C    29.0500  -18.9700
            13  O5a O    30.2400  -21.0700
            14  C1y C    36.3300  -17.5700
            15  C8x C    27.8600  -19.6700
            16  C8x C    29.0500  -17.6400
            17  C1x C    36.3300  -18.9700
            18  N1y N    37.5200  -16.8700
            19  C8x C    26.6700  -19.0400
            20  C8x C    27.8600  -16.9400
            21  C1x C    37.5200  -19.6700
            22  C1x C    38.7800  -17.5700
            23  C8y C    26.6700  -17.6400
            24  C1x C    38.7800  -18.9700
            25  O2a O    25.3400  -16.9400
            26  C1a C    24.1500  -17.6400
            27  C1a C    37.5200  -15.4700
BOND        28
            1     2   3 2
            2     2   4 1
            3     2   5 1
            4     3   6 1
            5     3   7 1
            6     4   8 1
            7     5   9 2
            8     6  10 1
            9     7  11 2
            10    8  12 1
            11    8  13 2
            12   10  14 1
            13   12  15 2
            14   12  16 1
            15   14  17 1
            16   14  18 1
            17   15  19 1
            18   16  20 2
            19   17  21 1
            20   18  22 1
            21   19  23 2
            22   21  24 1
            23   23  25 1
            24   25  26 1
            25    9  11 1
            26   20  23 1
            27   22  24 1
            28   18  27 1

» Japanese version   » Back

DBGET integrated database retrieval system