KEGG   DRUG: Encainide hydrochlorideHelp
Entry
D03991                      Drug                                   

Name
Encainide hydrochloride (USAN)
Formula
C22H28N2O2. HCl
Exact mass
388.1918
Mol weight
388.9309
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Cyp substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: 
Chemical group: 
Activity
Antiarrhythmic, Sodium channel blocker
Comment
Class I antiarrhythmic agent (Ic)
Target
SCN1A [HSA:6323] [KO:K04833];
SCN2A [HSA:6326] [KO:K04834];
SCN3A [HSA:6328] [KO:K04836];
SCN4A [HSA:6329] [KO:K04837];
SCN5A [HSA:6331] [KO:K04838];
SCN8A [HSA:6334] [KO:K04840];
SCN9A [HSA:6335] [KO:K04841];
SCN10A [HSA:6336] [KO:K04842]
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC08 Encainide
      D03991  Encainide hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
    voltage-gated sodium channel (SCN2A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
    voltage-gated sodium channel (SCN3A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
    voltage-gated sodium channel (SCN4A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
    voltage-gated sodium channel (SCN5A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
    voltage-gated sodium channel (SCN8A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
    voltage-gated sodium channel (SCN9A)
     Encainide
      D03991  Encainide hydrochloride (USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Encainide
    D03991  Encainide hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
66794-74-9
PubChem: 
ChEBI: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   X   Cl   41.7199  -19.3899
            2   C8y C    32.6900  -19.6700
            3   C8y C    33.8800  -18.9700
            4   N1b N    31.5000  -18.9700
            5   C8x C    32.6900  -21.0700
            6   C1b C    33.8800  -17.5700
            7   C8x C    35.1400  -19.6700
            8   C5a C    30.2400  -19.6700
            9   C8x C    33.8800  -21.7700
            10  C1b C    35.1400  -16.8700
            11  C8x C    35.1400  -21.0700
            12  C8y C    29.0500  -18.9700
            13  O5a O    30.2400  -21.0700
            14  C1y C    36.3300  -17.5700
            15  C8x C    27.8600  -19.6700
            16  C8x C    29.0500  -17.6400
            17  C1x C    36.3300  -18.9700
            18  N1y N    37.5200  -16.8700
            19  C8x C    26.6700  -19.0400
            20  C8x C    27.8600  -16.9400
            21  C1x C    37.5200  -19.6700
            22  C1x C    38.7800  -17.5700
            23  C8y C    26.6700  -17.6400
            24  C1x C    38.7800  -18.9700
            25  O2a O    25.3400  -16.9400
            26  C1a C    24.1500  -17.6400
            27  C1a C    37.5200  -15.4700
BOND        28
            1     2   3 2
            2     2   4 1
            3     2   5 1
            4     3   6 1
            5     3   7 1
            6     4   8 1
            7     5   9 2
            8     6  10 1
            9     7  11 2
            10    8  12 1
            11    8  13 2
            12   10  14 1
            13   12  15 2
            14   12  16 1
            15   14  17 1
            16   14  18 1
            17   15  19 1
            18   16  20 2
            19   17  21 1
            20   18  22 1
            21   19  23 2
            22   21  24 1
            23   23  25 1
            24   25  26 1
            25    9  11 1
            26   20  23 1
            27   22  24 1
            28   18  27 1

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