KEGG   DRUG: Ephedrine sulfateHelp
Entry
D04018                      Drug                                   

Name
Ephedrine sulfate (USP);
Isofedrol (TN)
Product
  Other
Formula
(C10H15NO)2. H2SO4
Exact mass
428.1981
Mol weight
428.5429
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01702  Phenethylamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
Remark
Activity
Antihypotensive, Bronchodilator, Adrenergic receptor agonist
Comment
Phenethylamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137];
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140];
ADRB1 [HSA:153] [KO:K04141];
ADRB2 [HSA:154] [KO:K04142];
ADRB3 [HSA:155] [KO:K04143]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA26 Ephedrine
      D04018  Ephedrine sulfate (USP)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA03 Ephedrine
      D04018  Ephedrine sulfate (USP)
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB05 Ephedrine
      D04018  Ephedrine sulfate (USP)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CA Alpha- and beta-adrenoreceptor agonists
     R03CA02 Ephedrine
      D04018  Ephedrine sulfate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FB Sympathomimetics excl. antiglaucoma preparations
     S01FB02 Ephedrine
      D04018  Ephedrine sulfate (USP)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Ephedrine
    D04018  Ephedrine sulfate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Ephedrine
      D04018  Ephedrine sulfate (USP)
    alpha2-adrenergic receptor
     Ephedrine
      D04018  Ephedrine sulfate (USP)
    beta1-adrenergic receptor
     Ephedrine
      D04018  Ephedrine sulfate (USP)
    beta2-adrenergic receptor
     Ephedrine
      D04018  Ephedrine sulfate (USP)
    beta3-adrenergic receptor
     Ephedrine
      D04018  Ephedrine sulfate (USP)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived by amination reactions
   Phenylalanine derived alkaloids
    D04018  Ephedrine sulfate (USP)
Rx-to-OTC switch list in the USA [br08315.html]
 D04018
BRITE hierarchy
Other DBs
CAS: 
134-72-5
PubChem: 
ChEMBL: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C8x C     4.7808   -5.6980
            2   C8x C     4.7808   -7.1001
            3   C8x C     5.9980   -7.8012
            4   C8x C     7.2081   -7.1001
            5   C8y C     7.2081   -5.6980
            6   C8x C     5.9980   -4.9969
            7   C1c C     8.4136   -4.9969
            8   C1c C     9.6245   -5.6908
            9   N1b N    10.8354   -4.9898
            10  C1a C    12.0464   -5.6837
            11  O1a O     8.4091   -3.5948
            12  C1a C     9.6275   -7.0930
            13  S4a S    18.7990   -5.6463
            14  O1d O    20.1988   -5.6463
            15  O1d O    17.3991   -5.6861
            16  O1d O    18.8618   -7.0461
            17  O1d O    18.8025   -4.2464
            18  C8x C     4.7808   -5.6980
            19  C8x C     5.9980   -4.9969
            20  C8y C     7.2081   -5.6980
            21  C1c C     8.4136   -4.9969
            22  C1c C     9.6245   -5.6908
            23  N1b N    10.8354   -4.9898
            24  C1a C    12.0464   -5.6837
            25  C1a C     9.6275   -7.0930
            26  O1a O     8.4091   -3.5948
            27  C8x C     7.2081   -7.1001
            28  C8x C     5.9980   -7.8012
            29  C8x C     4.7808   -7.1001
BOND        28
            1    13  14 1
            2    13  15 1
            3    13  16 2
            4    13  17 2
            5     6   1 1
            6     5   7 1
            7     1   2 2
            8     7   8 1
            9     2   3 1
            10    8   9 1
            11    3   4 2
            12    9  10 1
            13    4   5 1
            14    7  11 1 #Up
            15    5   6 2
            16    8  12 1 #Up
            17   19  18 1
            18   20  21 1
            19   18  29 2
            20   21  22 1
            21   29  28 1
            22   22  23 1
            23   28  27 2
            24   23  24 1
            25   27  20 1
            26   21  26 1 #Up
            27   20  19 2
            28   22  25 1 #Up
BRACKET     1     3.9900   -8.6800    3.9900   -2.7300
            1    13.9300   -2.7300   13.9300   -8.6800
            1  2
 ORIGINAL  1    1   6   5   7   8   9  10  12  11   4   3   2
 REPEAT    1   18  19  20  21  22  23  24  25  26  27  28  29

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