KEGG   DRUG: D04034Help
Entry
D04034                      Drug                                   

Name
Chlorpromazine phenolphthalinate (JAN);
Wintermin (TN)
Formula
C20H16O4. C17H19ClN2S
Exact mass
638.2006
Mol weight
639.2028
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotics
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
H1-receptor antagonist [HSA:3269] [KO:K04149];
alpha2-adrenergic receptor antagonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145];
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antipsychotics
Phenothiazines
Histamine H1 receptor antagonists
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AA Phenothiazines with aliphatic side-chain
     N05AA01 Chlorpromazine
      D04034  Chlorpromazine phenolphthalinate (JAN)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Chlorpromazine
    D04034  Chlorpromazine phenolphthalinate (JAN)
 Antipsychotics
  1st Generation/Typical
   Chlorpromazine
    D04034  Chlorpromazine phenolphthalinate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1171  Chlorpromazines
     D04034  Chlorpromazine phenolphthalinate (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Chlorpromazine
      D04034  Chlorpromazine phenolphthalinate (JAN)
   Adrenaline
    alpha2-adrenergic receptor
     Chlorpromazine
      D04034  Chlorpromazine phenolphthalinate (JAN)
   Dopamine
    dopamine D2-receptor
     Chlorpromazine
      D04034  Chlorpromazine phenolphthalinate (JAN)
   Histamine
    H1-receptor
     Chlorpromazine
      D04034  Chlorpromazine phenolphthalinate (JAN)
   Serotonin
    5-HT2-receptor
     Chlorpromazine
      D04034  Chlorpromazine phenolphthalinate (JAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Chlorpromazine
    D04034  Chlorpromazine phenolphthalinate (JAN)
 Inhbitors
  CYP2D6
   Chlorpromazine
    D04034  Chlorpromazine phenolphthalinate (JAN)
BRITE hierarchy
Other DBs
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        45
            1   C8x C     1.7565  -18.6515
            2   C8x C     1.7565  -20.0541
            3   C8x C     2.9711  -20.7554
            4   C8y C     4.1859  -20.0541
            5   C8y C     4.1859  -18.6515
            6   C8x C     2.9711  -17.9502
            7   S2x S     5.4006  -20.7554
            8   C8y C     6.6153  -20.0541
            9   C8y C     6.6153  -18.6515
            10  N4y N     5.4006  -17.9502
            11  C8x C     7.8301  -20.7554
            12  C8x C     9.0447  -20.0541
            13  C8y C     9.0447  -18.6515
            14  C8x C     7.8301  -17.9502
            15  C1b C     5.4006  -16.5475
            16  C1b C     6.6174  -15.8450
            17  C1b C     7.8161  -16.5373
            18  N1c N     9.0052  -15.8508
            19  C1a C    10.1989  -16.5403
            20  C1a C     9.0054  -14.4438
            21  X   Cl   10.2635  -17.9479
            22  C8x C    13.3000  -18.5500
            23  C8y C    13.3000  -19.9500
            24  C8x C    14.5124  -20.6500
            25  C8x C    15.7249  -19.9500
            26  C8y C    15.7249  -18.5500
            27  C8x C    14.5124  -17.8500
            28  C8x C    18.1497  -19.9500
            29  C8y C    18.1497  -18.5500
            30  C1c C    16.9373  -17.8500
            31  C8x C    19.3622  -20.6500
            32  C8y C    20.5746  -19.9500
            33  C8x C    20.5746  -18.5500
            34  C8x C    19.3622  -17.8500
            35  C8y C    16.9373  -16.4500
            36  C8y C    18.1518  -15.7488
            37  C8x C    18.1518  -14.3488
            38  C8x C    16.9393  -13.6488
            39  C8x C    15.7249  -14.3500
            40  C8x C    15.7249  -15.7500
            41  O1a O    12.0876  -20.6500
            42  O1a O    21.7911  -20.6523
            43  C6a C    19.5518  -15.7488
            44  O6a O    20.2466  -16.9527
            45  O6a O    20.2457  -14.5468
BOND        49
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   10  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   18  20 1
            23   13  21 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   22  27 1
            30   28  29 1
            31   29  30 1
            32   26  30 1
            33   28  31 2
            34   31  32 1
            35   32  33 2
            36   33  34 1
            37   29  34 2
            38   30  35 1
            39   35  36 2
            40   36  37 1
            41   37  38 2
            42   38  39 1
            43   39  40 2
            44   35  40 1
            45   23  41 1
            46   32  42 1
            47   36  43 1
            48   43  44 2
            49   43  45 1

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