KEGG   DRUG: D04048Help
Entry
D04048                      Drug                                   

Name
Ropivacaine hydrochloride hydrate (JAN);
Ropivacaine hydrochloride (USP);
Anapeine (TN)
Product
  Other
Formula
C17H26N2O. HCl. H2O
Exact mass
328.1918
Mol weight
328.8774
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant
Remark
Therapeutic category: 
ATC code: 
Target
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842];
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Sodium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D04048  Ropivacaine hydrochloride hydrate (JAN); Ropivacaine hydrochloride (USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB09 Ropivacaine
      D04048  Ropivacaine hydrochloride hydrate (JAN); Ropivacaine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833]
     Ropivacaine [ATC:N01BB09]
      D04048  Ropivacaine hydrochloride hydrate (JAN); Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834]
     Ropivacaine [ATC:N01BB09]
      D04048  Ropivacaine hydrochloride hydrate (JAN); Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836]
     Ropivacaine [ATC:N01BB09]
      D04048  Ropivacaine hydrochloride hydrate (JAN); Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837]
     Ropivacaine [ATC:N01BB09]
      D04048  Ropivacaine hydrochloride hydrate (JAN); Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838]
     Ropivacaine [ATC:N01BB09]
      D04048  Ropivacaine hydrochloride hydrate (JAN); Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840]
     Ropivacaine [ATC:N01BB09]
      D04048  Ropivacaine hydrochloride hydrate (JAN); Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841]
     Ropivacaine [ATC:N01BB09]
      D04048  Ropivacaine hydrochloride hydrate (JAN); Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN10A) [HSA:6336] [KO:K04842]
     Ropivacaine [ATC:N01BB09]
      D04048  Ropivacaine hydrochloride hydrate (JAN); Ropivacaine hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
132112-35-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   X   Cl   31.2200  -18.2001
            2   O0  O    31.7800  -21.0001
            3   C8x C    20.8600  -18.3400
            4   C8x C    20.8600  -19.7400
            5   C8y C    22.0500  -20.4400
            6   C8y C    23.3100  -19.7400
            7   C8y C    23.3100  -18.3400
            8   C8x C    22.0500  -17.6400
            9   N1b N    24.5000  -20.4400
            10  C5a C    25.6900  -19.7400
            11  C1a C    24.5000  -17.6400
            12  C1y C    26.9500  -20.4400
            13  N1y N    26.9500  -21.8400
            14  C1x C    28.1400  -22.5400
            15  C1x C    29.3300  -21.8400
            16  C1x C    29.3300  -20.4400
            17  C1x C    28.1400  -19.7400
            18  C1a C    22.0500  -21.8400
            19  C1b C    25.6900  -22.5400
            20  C1b C    24.5000  -21.8400
            21  C1a C    23.3100  -22.5400
            22  O5a O    25.6900  -18.3400
BOND        21
            1     3   4 2
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     3   8 1
            7     6   9 1
            8     9  10 1
            9     7  11 1
            10   12  10 1 #Down
            11   12  13 1
            12   13  14 1
            13   14  15 1
            14   15  16 1
            15   16  17 1
            16   12  17 1
            17    5  18 1
            18   13  19 1
            19   19  20 1
            20   20  21 1
            21   10  22 2

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