KEGG   DRUG: Ropivacaine hydrochlorideHelp
Entry
D04048                      Drug                                   

Name
Ropivacaine hydrochloride (USP);
Ropivacaine hydrochloride hydrate (JAN);
Anapeine (TN)
Product
  Generic
Formula
C17H26N2O. HCl. H2O
Exact mass
328.1918
Mol weight
328.8774
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01675  Local anesthetic
  DG01673  Amide type local anesthetic
Cyp substrate
 DG01892  CYP1A2 substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Anesthetic (local)
Target
SCN10A [HSA:6336] [KO:K04842];
SCN1A [HSA:6323] [KO:K04833];
SCN2A [HSA:6326] [KO:K04834];
SCN3A [HSA:6328] [KO:K04836];
SCN4A [HSA:6329] [KO:K04837];
SCN5A [HSA:6331] [KO:K04838];
SCN8A [HSA:6334] [KO:K04840];
SCN9A [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB09 Ropivacaine
      D04048  Ropivacaine hydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D04048  Ropivacaine hydrochloride (USP); Ropivacaine hydrochloride hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Ropivacaine
      D04048  Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN2A)
     Ropivacaine
      D04048  Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN3A)
     Ropivacaine
      D04048  Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN4A)
     Ropivacaine
      D04048  Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN5A)
     Ropivacaine
      D04048  Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN8A)
     Ropivacaine
      D04048  Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN9A)
     Ropivacaine
      D04048  Ropivacaine hydrochloride (USP)
    voltage-gated sodium channel (SCN10A)
     Ropivacaine
      D04048  Ropivacaine hydrochloride (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Ropivacaine
    D04048  Ropivacaine hydrochloride (USP)
Anesthetics, analgesics and anti-inflammatory drugs [br08369.html]
 Anesthetics
  D04048
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04048
BRITE hierarchy
Other DBs
CAS: 
132112-35-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   X   Cl   31.2200  -18.2001
            2   O0  O    31.7800  -21.0001
            3   C8x C    20.8600  -18.3400
            4   C8x C    20.8600  -19.7400
            5   C8y C    22.0500  -20.4400
            6   C8y C    23.3100  -19.7400
            7   C8y C    23.3100  -18.3400
            8   C8x C    22.0500  -17.6400
            9   N1b N    24.5000  -20.4400
            10  C5a C    25.6900  -19.7400
            11  C1a C    24.5000  -17.6400
            12  C1y C    26.9500  -20.4400
            13  N1y N    26.9500  -21.8400
            14  C1x C    28.1400  -22.5400
            15  C1x C    29.3300  -21.8400
            16  C1x C    29.3300  -20.4400
            17  C1x C    28.1400  -19.7400
            18  C1a C    22.0500  -21.8400
            19  C1b C    25.6900  -22.5400
            20  C1b C    24.5000  -21.8400
            21  C1a C    23.3100  -22.5400
            22  O5a O    25.6900  -18.3400
BOND        21
            1     3   4 2
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     3   8 1
            7     6   9 1
            8     9  10 1
            9     7  11 1
            10   12  10 1 #Down
            11   12  13 1
            12   13  14 1
            13   14  15 1
            14   15  16 1
            15   16  17 1
            16   12  17 1
            17    5  18 1
            18   13  19 1
            19   19  20 1
            20   20  21 1
            21   10  22 2

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