KEGG   DRUG: D04292Help
Entry
D04292                      Drug                                   

Name
Galantamine (USAN/INN);
Reminyl (TN)
Formula
C17H21NO3
Exact mass
287.1521
Mol weight
287.3535
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Galanthus woronowii [TAX:197699]
Activity
Alzheimer's disease treatment [cholinesterase inhibitor] [DS:H00056]
Remark
Same as: 
ATC code: 
Drug group: 
Target
acetylcholinesterase (AChE) inhibitor [HSA:43] [KO:K01049];
nicotinic acetylcholine receptor (nAChR) allosteric site agonist
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse  
 
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA04 Galantamine
      D04292  Galantamine (USAN/INN)
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Galantamine
    D04292  Galantamine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Galantamine
     D04292  Galantamine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
357-70-0
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C8y C    26.6000  -12.1800
            2   C1x C    27.6500  -12.9500
            3   N1y N    28.9800  -12.6700
            4   C1x C    29.5400  -11.4100
            5   C8y C    26.6000  -10.7800
            6   C1x C    28.9800  -10.2200
            7   C1z C    27.6500   -9.7300
            8   C1a C    29.8900  -13.7200
            9   C8x C    25.4100  -12.8800
            10  C8x C    24.2200  -12.1800
            11  C8y C    24.2200  -10.7800
            12  C8y C    25.4100  -10.0800
            13  O2a O    23.0300  -10.1500
            14  O2x O    25.7600   -8.4700
            15  C1y C    27.1600   -8.4000
            16  C1x C    27.7900   -7.2800
            17  C1y C    29.1900   -7.2800
            18  C2x C    29.8900   -8.4700
            19  C2x C    29.1900   -9.7300
            20  O1a O    29.8900   -6.0200
            21  C1a C    21.8441  -10.8940
BOND        24
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     7   6 1 #Down
            8     3   8 1
            9     1   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    5  12 1
            14   11  13 1
            15   12  14 1
            16   14  15 1
            17    7  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21    7  19 1
            22   19  18 2
            23   17  20 1 #Up
            24   13  21 1

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