KEGG   DRUG: D04358Help
Entry
D04358                      Drug                                   

Name
Golimumab (genetical recombination) (JAN);
Golimumab (USAN/INN);
Simponi (TN)
Product
Formula
C6530H10068N1752O2026S44
Exact mass
146852.6362
Mol weight
146943.1937
Activity
Treatment of inflammatory disorders, rheumatoid arthritis, uveitis, asthma and Crohn's disease [DS:H00630]
Remark
Therapeutic category: 
ATC code: 
Comment
monoclonal antibody
Target
TNF-alpha [HSA:7124] [KO:K03156]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04350  TGF-beta signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa05310  Asthma
hsa05323  Rheumatoid arthritis  
 
Interaction
Drug interaction
Structure map
Antirheumatics - DMARDs and biological agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D04358  Golimumab (genetical recombination) (JAN); Golimumab (USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AB Tumor necrosis factor alpha (TNF-alpha) inhibitors
     L04AB06 Golimumab
      D04358  Golimumab (genetical recombination) (JAN); Golimumab (USAN/INN)
USP drug classification [BR:br08302]
 Immunological Agents
  Immune Suppressants
   Golimumab
    D04358  Golimumab (genetical recombination) (JAN); Golimumab (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines
  TNF family
   TNF-alpha [HSA:7124] [KO:K03156]
    Golimumab [ATC:L04AB06]
     D04358  Golimumab (genetical recombination) (JAN); Golimumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
476181-74-5
PubChem: 

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