KEGG   DRUG: D04405Help
Entry
D04405                      Drug                                   

Name
Goserelin (USAN/INN)
Formula
C59H84N18O14
Exact mass
1268.6414
Mol weight
1269.4105
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
LHRH agonist [DS:H00024]
Remark
ATC code: 
Comment
Goserelin cause downregulation of gonadotropin-releasing hormone (GnRH) receptor.
Target
gonadotropin-releasing hormone (GnRH) receptor agonist [HSA:2798] [KO:K04280]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04912  GnRH signaling pathway  
 
Interaction
Drug interaction
Structure map
Antineoplastics - hormones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02A HORMONES AND RELATED AGENTS
    L02AE Gonadotropin releasing hormone analogues
     L02AE03 Goserelin
      D04405  Goserelin (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Gonadotropin-releasing hormone
    gonadotropin-releasing hormone (GnRH) receptor [HSA:2798] [KO:K04280]
     Goserelin [ATC:L02AE03]
      D04405  Goserelin (USAN/INN)
Antineoplastics [BR:br08308]
 Hormones and hormone antagonist
  Lutenizing hormone-releasing hormone agonist
   Goserelin [ATC:L02AE03]
    D04405  Goserelin (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
65807-02-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        91
            1   C8y C    12.3833  -14.2064
            2   C8y C    12.8031  -12.8767
            3   C1b C    11.1935  -14.9061
            4   C8x C    13.5030  -15.0461
            5   C8y C    14.2027  -12.8767
            6   C8x C    12.1734  -11.6870
            7   C1c C    11.1935  -16.3058
            8   N4x N    14.6226  -14.2064
            9   C8x C    14.9026  -11.6870
            10  C8x C    12.8731  -10.4973
            11  N1b N    10.0039  -17.0056
            12  C5a C    12.3833  -17.0056
            13  C8x C    14.2027  -10.4973
            14  C5a C     8.7443  -16.3058
            15  N1b N    13.5730  -16.3058
            16  O5a O    12.3833  -18.4052
            17  C1c C     7.5546  -17.0056
            18  O5a O     8.7443  -14.9061
            19  C1c C    14.7627  -17.0056
            20  C1b C     7.5546  -18.4052
            21  N1b N     6.3649  -16.3058
            22  C5a C    16.0223  -16.3058
            23  C1b C    14.7627  -18.4052
            24  C8y C     8.7443  -19.0350
            25  C5a C     5.1752  -17.0056
            26  N1b N    17.2119  -17.0056
            27  O5a O    16.0223  -14.9061
            28  O1a O    16.0223  -19.0350
            29  C8x C    10.1439  -18.6851
            30  N5x N     8.7443  -20.4346
            31  C1y C     3.9856  -16.3058
            32  O5a O     5.1752  -18.4052
            33  C1c C    18.4016  -16.3058
            34  N4x N    10.8437  -19.8748
            35  C8x C    10.0039  -20.9245
            36  C1x C     2.6559  -16.7256
            37  N1x N     3.9856  -14.9061
            38  C1b C    18.4016  -14.9061
            39  C5a C    19.5913  -17.0056
            40  C1x C     1.8161  -15.6060
            41  C5x C     2.6559  -14.4862
            42  C8y C    19.5913  -14.2064
            43  N1b N    20.7810  -16.3058
            44  O5a O    19.5913  -18.4052
            45  O5x O     2.2360  -13.1566
            46  C8x C    20.7810  -14.9061
            47  C8x C    19.5913  -12.8067
            48  C1c C    21.9706  -17.0056
            49  C8x C    21.9706  -14.2064
            50  C8x C    20.7810  -12.1069
            51  C5a C    23.2303  -16.3058
            52  C1b C    21.9706  -18.4052
            53  C8y C    21.9706  -12.8067
            54  N1b N    24.4200  -17.0056
            55  O5a O    23.2303  -14.9061
            56  O2a O    20.7810  -19.0350
            57  O1a O    23.1604  -12.1069
            58  C1c C    25.6097  -16.3058
            59  C1d C    20.7810  -20.4346
            60  C5a C    26.7994  -17.0056
            61  C1b C    25.6097  -14.9061
            62  C1a C    20.7810  -21.9043
            63  C1a C    22.1806  -20.4346
            64  C1a C    19.5214  -20.4346
            65  N1b N    27.9890  -16.3058
            66  O5a O    26.7994  -18.4052
            67  C1c C    26.7994  -14.2064
            68  C1c C    29.1787  -17.0056
            69  C1a C    26.7994  -12.8067
            70  C1a C    27.9890  -14.9061
            71  C5a C    30.4384  -16.3058
            72  C1b C    29.1787  -18.4052
            73  N1y N    31.6281  -17.0056
            74  O5a O    30.4384  -14.9061
            75  C1b C    27.9890  -19.0350
            76  C1y C    33.0277  -17.0056
            77  C1x C    31.2082  -18.3352
            78  C1b C    27.9890  -20.4346
            79  C1x C    33.4476  -18.2652
            80  C5a C    34.2174  -16.2357
            81  C1x C    32.3279  -19.1050
            82  N1b N    26.7994  -21.1345
            83  N1b N    35.4071  -16.9356
            84  O5a O    34.2174  -14.9061
            85  C2c C    25.6097  -20.4346
            86  N1a N    24.4200  -21.1345
            87  N2a N    25.6097  -19.0350
            88  N1b N    36.6301  -16.2360
            89  C5a C    37.8263  -16.9332
            90  N1a N    39.0188  -16.2512
            91  O5a O    37.8207  -18.3398
BOND        96
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     6  10 2
            10    7  11 1
            11    7  12 1 #Up
            12    9  13 2
            13   11  14 1
            14   12  15 1
            15   12  16 2
            16   14  17 1
            17   14  18 2
            18   19  15 1 #Down
            19   17  20 1 #Down
            20   17  21 1
            21   19  22 1
            22   19  23 1
            23   20  24 1
            24   21  25 1
            25   22  26 1
            26   22  27 2
            27   23  28 1
            28   24  29 2
            29   24  30 1
            30   31  25 1 #Down
            31   25  32 2
            32   26  33 1
            33   29  34 1
            34   30  35 2
            35   31  36 1
            36   31  37 1
            37   33  38 1 #Up
            38   33  39 1
            39   36  40 1
            40   37  41 1
            41   38  42 1
            42   39  43 1
            43   39  44 2
            44   41  45 2
            45   42  46 2
            46   42  47 1
            47   43  48 1
            48   46  49 1
            49   47  50 2
            50   48  51 1
            51   48  52 1 #Up
            52   49  53 2
            53   51  54 1
            54   51  55 2
            55   52  56 1
            56   53  57 1
            57   54  58 1
            58   56  59 1
            59   58  60 1
            60   58  61 1 #Up
            61   59  62 1
            62   59  63 1
            63   59  64 1
            64   60  65 1
            65   60  66 2
            66   61  67 1
            67   65  68 1
            68   67  69 1
            69   67  70 1
            70   68  71 1
            71   68  72 1 #Down
            72   71  73 1
            73   71  74 2
            74   72  75 1
            75   73  76 1
            76   73  77 1
            77   75  78 1
            78   76  79 1
            79   76  80 1 #Down
            80   77  81 1
            81   78  82 1
            82   80  83 1
            83   80  84 2
            84   82  85 1
            85   85  86 1
            86   85  87 2
            87    5   8 1
            88   10  13 1
            89   34  35 1
            90   40  41 1
            91   50  53 1
            92   79  81 1
            93   83  88 1
            94   88  89 1
            95   89  90 1
            96   89  91 2

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