KEGG   DRUG: Insulin lisproHelp
Entry
D04477                      Drug                                   

Name
Insulin lispro (USP/INN);
Insulin lispro (genetical recombination) (JAN);
Humalog (TN)
Product
Formula
C257H383N65O77S6
Exact mass
5803.6376
Mol weight
5807.5702
Sequence
(A chain) Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr
Gln Leu Glu Asn Tyr Cys Asn (Disulfide bridge: 6-11)
(B chain) Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala
Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr
(Disulfide bridge: A7-B7; A20-B19)
  Type
Peptide
Class
Antidiabetic agent
 DG01636  Insulin and analogue
  DG01801  Insulin analogue
   DG01796  Insulin analogue, fast-acting
Cyp inducer
 DG01637  CYP1A2 inducer
Remark
Therapeutic category: 
ATC code: 
Activity
Antidiabetic
Target
insulin receptor [HSA:3643] [KO:K04527]
  Pathway
Insulin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Interaction
CYP induction: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10A INSULINS AND ANALOGUES
    A10AB Insulins and analogues for injection, fast-acting
     A10AB04 Insulin lispro
      D04477  Insulin lispro (USP/INN)
    A10AC Insulins and analogues for injection, intermediate-acting
     A10AC04 Insulin lispro
      D04477  Insulin lispro (USP/INN)
    A10AD Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
     A10AD04 Insulin lispro
      D04477  Insulin lispro (USP/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Insulins
   Insulin lispro
    D04477  Insulin lispro (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2492  Pancreatic hormones
     D04477  Insulin lispro (USP/INN); Insulin lispro (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class II (Insulin receptor family)
    insulin receptor
     Insulin lispro
      D04477  Insulin lispro (USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inducers
  CYP1A2
   Insulin lispro
    D04477  Insulin lispro (USP/INN)
Antidiabetics [br08361.html]
 D04477
BRITE hierarchy
Other DBs
CAS: 
133107-64-9
PubChem: 
DrugBank: 

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