KEGG   DRUG: D04477Help
Entry
D04477                      Drug                                   

Name
Insulin lispro (genetical recombination) (JAN);
Insulin lispro (USP/INN);
Humalog (TN)
Product
Formula
C257H383N65O77S6
Exact mass
5803.6376
Mol weight
5807.5702
Sequence
(A chain) Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr
Gln Leu Glu Asn Tyr Cys Asn (Disulfide bridge: 6-11)
(B chain) Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala
Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr
(Disulfide bridge: A7-B7; A20-B19)
  Type
Peptide
Activity
Antidiabetic [DS:H00408 H00409]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
insulin receptor agonist [HSA:3643] [KO:K04527]
  Pathway
hsa04910  Insulin signaling pathway
hsa04930  Type II diabetes mellitus
hsa04960  Aldosterone-regulated sodium reabsorption  
 
Interaction
CYP induction: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10A INSULINS AND ANALOGUES
    A10AB Insulins and analogues for injection, fast-acting
     A10AB04 Insulin lispro
      D04477  Insulin lispro (genetical recombination) (JAN); Insulin lispro (USP/INN)
    A10AC Insulins and analogues for injection, intermediate-acting
     A10AC04 Insulin lispro
      D04477  Insulin lispro (genetical recombination) (JAN); Insulin lispro (USP/INN)
    A10AD Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
     A10AD04 Insulin lispro
      D04477  Insulin lispro (genetical recombination) (JAN); Insulin lispro (USP/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Insulins
   Insulin lispro
    D04477  Insulin lispro (genetical recombination) (JAN); Insulin lispro (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2492  Pancreatic hormones
     D04477  Insulin lispro (genetical recombination) (JAN); Insulin lispro (USP/INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class II (Insulin receptor family)
    insulin receptor
     Insulin lispro
      D04477  Insulin lispro (genetical recombination) (JAN); Insulin lispro (USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Inducers
  CYP1A2
   Insulin lispro
    D04477  Insulin lispro (genetical recombination) (JAN); Insulin lispro (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
133107-64-9
PubChem: 
DrugBank: 

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