KEGG   DRUG: Insulin detemirHelp
Entry
D04539                      Drug                                   

Name
Insulin detemir (USAN/INN);
Insulin detemir (genetical recombination) (JAN);
Levemir (TN)
Product
Formula
C267H402N64O76S6
Exact mass
5912.7883
Mol weight
5916.822
Sequence
(A chain) Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr
Gln Leu Glu Asn Tyr Cys Asn (Disulfide bridge: 6-11)
(B chain) Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala
Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro
Lys-C14H27O (Disulfide bridge: A7-B7; A20-B19)
  Type
Peptide
Class
Antidiabetic agent
 DG01636  Insulin and analogue
  DG01801  Insulin analogue
   DG01797  Insulin analogue, long-acting
Cyp inducer
 DG01637  CYP1A2 inducer
Remark
Therapeutic category: 
ATC code: 
Activity
Antidiabetic
Target
insulin receptor [HSA:3643] [KO:K04527]
  Pathway
Insulin signaling pathway
Type II diabetes mellitus
Interaction
CYP induction: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10A INSULINS AND ANALOGUES
    A10AE Insulins and analogues for injection, long-acting
     A10AE05 Insulin detemir
      D04539  Insulin detemir (USAN/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Insulins
   Insulin detemir
    D04539  Insulin detemir (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2492  Pancreatic hormones
     D04539  Insulin detemir (USAN/INN); Insulin detemir (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class II (Insulin receptor family)
    insulin receptor
     Insulin detemir
      D04539  Insulin detemir (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inducers
  CYP1A2
   Insulin detemir
    D04539  Insulin detemir (USAN/INN)
Antidiabetics [br08361.html]
 D04539
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D04539
BRITE hierarchy
Other DBs
CAS: 
169148-63-4
PubChem: 
NIKKAJI: 

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