KEGG   DRUG: D04540Help
Entry
D04540                      Drug                                   

Name
Insulin glulisine (genetical recombination) (JAN);
Insulin glulisine (USAN/INN);
Apidra (TN)
Product
Formula
C258H384N64O78S6
Exact mass
5818.6373
Mol weight
5822.5816
Sequence
(A chain) Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr
Gln Leu Glu Asn Tyr Cys Asn (Disulfide bridge: 6-11)
(B chain) Phe Val Lys Gln His Leu Cys Gly Ser His Leu Val Glu Ala
Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Glu Thr
(Disulfide bridge: A7-B7; A20-B19)
  Type
Peptide
Activity
Treatment of type 1 and type 2 diabetes [DS:H00408 H00409]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
insulin receptor agonist [HSA:3643] [KO:K04527]
  Pathway
hsa04910  Insulin signaling pathway
hsa04930  Type II diabetes mellitus
hsa04960  Aldosterone-regulated sodium reabsorption  
 
Interaction
CYP induction: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10A INSULINS AND ANALOGUES
    A10AB Insulins and analogues for injection, fast-acting
     A10AB06 Insulin glulisine
      D04540  Insulin glulisine (genetical recombination) (JAN); Insulin glulisine (USAN/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Insulins
   Insulin glulisine
    D04540  Insulin glulisine (genetical recombination) (JAN); Insulin glulisine (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2492  Pancreatic hormones
     D04540  Insulin glulisine (genetical recombination) (JAN); Insulin glulisine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class II (Insulin receptor family)
    insulin receptor
     Insulin glulisine
      D04540  Insulin glulisine (genetical recombination) (JAN); Insulin glulisine (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Inducers
  CYP1A2
   Insulin glulisine
    D04540  Insulin glulisine (genetical recombination) (JAN); Insulin glulisine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
207748-29-6
PubChem: 

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