KEGG   DRUG: Interferon beta-1a
Entry
D04554                      Drug                                   
Name
Interferon beta-1a (USAN);
Interferon beta-1a (genetical recombination) (JAN);
Avonex (TN);
Rebif (TN)
Product
INTERFERON BETA-1A (Biogen), INTERFERON BETA-1A (EMD Serono)
Formula
C908H1406N246O252S7
Exact mass
20012.2812
Mol weight
20024.8312
Sequence
MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY
EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL
HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN
(Disulfide bridge: 31-141)
  Type
Peptide
Class
Immunological agent
 DG01752  Interferone
Remark
Therapeutic category: 6399
ATC code: L03AB07
Chemical structure group: DG01751
Product (DG01751): D00746<JP/US> D03304<JP> D04554<JP/US>
Efficacy
Antineoplastic, Biological response modifier
  Disease
Multiple sclerosis [DS:H01490]
Target
IFNAR1 [HSA:3454] [KO:K05130]
IFNAR2 [HSA:3455] [KO:K05131]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04620  Toll-like receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AB Interferons
     L03AB07 Interferon beta-1a
      D04554  Interferon beta-1a (USAN) <JP/US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Multiple Sclerosis Agents
   Interferon Beta-1a
    D04554  Interferon beta-1a (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   639  Miscellaneous
    6399  Others
     D04554  Interferon beta-1a (USAN); Interferon beta-1a (genetical recombination) (JAN)
Drug groups [BR:br08330]
 Immunological agent
  DG01752  Interferone
   DG01751  Interferon beta
    D04554  Interferon beta-1a
Drug classes [BR:br08332]
 Immunological agent
  DG01752  Interferone
   D04554  Interferon beta-1a
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Interferon receptors
    IFNAR1
     D04554  Interferon beta-1a (USAN) <JP/US>
    IFNAR2
     D04554  Interferon beta-1a (USAN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04554
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04554
Drug groups [BR:br08330]
 Immunological agent
  DG01752  Interferone
   DG01751  Interferon beta
Other DBs
CAS: 145258-61-3
PubChem: 47206399

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Ontology (8)   
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Disease (1)   
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Drug (1)   
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