KEGG   DRUG: D04554Help
Entry
D04554                      Drug                                   

Name
Interferon beta-1a (genetical recombination) (JAN);
Interferon beta-1a (USAN);
Avonex (TN);
Rebif (TN)
Product
Formula
C908H1406N246O252S7
Exact mass
20012.2812
Mol weight
20024.8312
Sequence
MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY
EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL
HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN
(Disulfide bridge: 31-141)
  Type
Peptide
Activity
Antineoplastic;
Biological response modifier
Remark
Therapeutic category: 
ATC code: 
Target
interferon receptor 1 agonist [HSA:3454] [KO:K05130];
interferon receptor 2 agonist [HSA:3455] [KO:K05131]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04380  Osteoclast differentiation
hsa04620  Toll-like receptor signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity  
 
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   639  Miscellaneous
    6399  Others
     D04554  Interferon beta-1a (genetical recombination) (JAN); Interferon beta-1a (USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AB Interferons
     L03AB07 Interferon beta-1a
      D04554  Interferon beta-1a (genetical recombination) (JAN); Interferon beta-1a (USAN)
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Multiple Sclerosis Agents
   Interferon beta-1a
    D04554  Interferon beta-1a (genetical recombination) (JAN); Interferon beta-1a (USAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class II cytokine receptors (interferon/IL-10 family receptors)
   interferon receptor 1 [HSA:3454] [KO:K05130]
    Interferon beta-1a [ATC:L03AB07]
     D04554  Interferon beta-1a (genetical recombination) (JAN); Interferon beta-1a (USAN)
   interferon receptor 2 [HSA:3455] [KO:K05131]
    Interferon beta-1a [ATC:L03AB07]
     D04554  Interferon beta-1a (genetical recombination) (JAN); Interferon beta-1a (USAN)
BRITE hierarchy
Other DBs
CAS: 
145258-61-3
PubChem: 
DrugBank: 

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