KEGG   DRUG: D04657Help
Entry
D04657                      Drug                                   

Name
Lacidipine (USAN/INN);
Motens (TN)
Formula
C26H33NO6
Exact mass
455.2308
Mol weight
455.5433
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
ATC code: 
Drug group: 
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cardiac muscle contraction
Vascular smooth muscle contraction
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA09 Lacidipine
      D04657  Lacidipine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Lacidipine
      D04657  Lacidipine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
103890-78-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C1y C    30.7658  -15.9980
            2   C8y C    30.8182  -18.2612
            3   C2y C    29.5904  -15.3231
            4   C2y C    31.9409  -15.3290
            5   C8x C    29.6371  -18.9361
            6   C8y C    31.9935  -18.9478
            7   C2y C    29.5963  -13.9617
            8   C7a C    28.4093  -15.9923
            9   C2y C    31.9468  -13.9734
            10  C7a C    33.1104  -16.0096
            11  C8x C    29.6371  -20.2975
            12  C8x C    31.9877  -20.2975
            13  N1x N    30.7715  -13.2868
            14  C1a C    28.4209  -13.2811
            15  O7a O    27.2400  -15.3174
            16  O6a O    28.4093  -17.3594
            17  C1a C    33.1220  -13.2928
            18  O7a O    34.2914  -15.3406
            19  O6a O    33.1046  -17.3710
            20  C8x C    30.8066  -20.9782
            21  C1b C    26.0648  -15.9923
            22  C1b C    35.4667  -16.0212
            23  C1a C    24.8895  -15.3115
            24  C1a C    36.6913  -15.3163
            25  C2b C    33.2154  -18.2501
            26  C2b C    34.3974  -18.9401
            27  C7a C    35.5884  -18.2599
            28  O7a O    36.7621  -18.9450
            29  O6a O    35.5258  -16.8532
            30  C1d C    37.9573  -18.2623
            31  C1a C    39.3583  -17.4419
            32  C1a C    38.6325  -19.4451
            33  C1a C    37.2518  -17.0264
BOND        34
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    7  14 1
            14    8  15 1
            15    8  16 2
            16    9  17 1
            17   10  18 1
            18   10  19 2
            19   11  20 2
            20   15  21 1
            21   18  22 1
            22   21  23 1
            23    9  13 1
            24   12  20 1
            25   22  24 1
            26    6  25 1
            27   25  26 2
            28   26  27 1
            29   27  28 1
            30   27  29 2
            31   28  30 1
            32   30  31 1
            33   30  32 1
            34   30  33 1

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