KEGG   DRUG: D04657Help
Entry
D04657                      Drug                                   

Name
Lacidipine (USAN/INN);
Motens (TN)
Formula
C26H33NO6
Exact mass
455.2308
Mol weight
455.5433
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
ATC code: 
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA09 Lacidipine
      D04657  Lacidipine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Lacidipine
      D04657  Lacidipine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
103890-78-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C1y C    30.7658  -15.9980
            2   C8y C    30.8182  -18.2612
            3   C2y C    29.5904  -15.3231
            4   C2y C    31.9409  -15.3290
            5   C8x C    29.6371  -18.9361
            6   C8y C    31.9935  -18.9478
            7   C2y C    29.5963  -13.9617
            8   C7a C    28.4093  -15.9923
            9   C2y C    31.9468  -13.9734
            10  C7a C    33.1104  -16.0096
            11  C8x C    29.6371  -20.2975
            12  C8x C    31.9877  -20.2975
            13  N1x N    30.7715  -13.2868
            14  C1a C    28.4209  -13.2811
            15  O7a O    27.2400  -15.3174
            16  O6a O    28.4093  -17.3594
            17  C1a C    33.1220  -13.2928
            18  O7a O    34.2914  -15.3406
            19  O6a O    33.1046  -17.3710
            20  C8x C    30.8066  -20.9782
            21  C1b C    26.0648  -15.9923
            22  C1b C    35.4667  -16.0212
            23  C1a C    24.8895  -15.3115
            24  C1a C    36.6913  -15.3163
            25  C2b C    33.2154  -18.2501
            26  C2b C    34.3974  -18.9401
            27  C7a C    35.5884  -18.2599
            28  O7a O    36.7621  -18.9450
            29  O6a O    35.5258  -16.8532
            30  C1d C    37.9573  -18.2623
            31  C1a C    39.3583  -17.4419
            32  C1a C    38.6325  -19.4451
            33  C1a C    37.2518  -17.0264
BOND        34
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    7  14 1
            14    8  15 1
            15    8  16 2
            16    9  17 1
            17   10  18 1
            18   10  19 2
            19   11  20 2
            20   15  21 1
            21   18  22 1
            22   21  23 1
            23    9  13 1
            24   12  20 1
            25   22  24 1
            26    6  25 1
            27   25  26 2
            28   26  27 1
            29   27  28 1
            30   27  29 2
            31   28  30 1
            32   30  31 1
            33   30  32 1
            34   30  33 1

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